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Lady depressed on tamoxifen maintenance therapy.

Posted by Sparkboy on September 8, 2000, at 15:07:40

Hello. I'm looking for something to help a lady who
has depression with spells of feeling suicidal. She is
taking tamoxifen to prevent a recurrence of estrogen
responsive breast cancer. She is using soy products
to try to alleviate the side-effects. Her
pdoc is certain the depression is being caused by the
estrogen receptor blockade of the tamoxifen. She is
getting modest relief from Celexa combined with Fastin
(phentermine). I've done a MEDLINE search and haven't
found anything useful on this topic. Just as a guess,
I'm wondering if progesterone could help. Any insights
on the mechanisms involved and how to counter it would be
greatly appreciated.

Thanks
--John


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