Posted by AndrewB on August 30, 2000, at 1:28:21
In reply to Re: SSRI fatigue and memory loss » Anthony, posted by Jonathan on August 29, 2000, at 21:29:19
Jonathan,
I really like it when you post. You are so well informed. Thank you for the info on 5-HT3 receptor function.
Concerning Ondansetron and fatigue, two other people other than me have noted its mental arousal effects. In a letter to the editor of Lancet (July 31, ‘99) a Dr. Jones noted that Ondansetron relieved the fatigue of a hepatitis C patient. In the letter Dr. Jones speculates that altered serotenergic transmission can be a cause of profound fatigue. In support of this idea he mentions a study where the exercise endurance of atheletes was decreased after taking Paxil. These atheletes were not depressed.
This information only suggests that Ondansetron may be able to relieve SSRI induced fatigue. Hopefully someone who has SSRI fatigue will try Ondasetron and let us know what happens.
By the way, I also had what I call partial poop out of reboxetine after 4 or so months on it. I however was using it as an arousal agent, not an AD. As I said, it lost most of its effectiveness after awhile.
This is something I know nothing about, but Jonathan have you looked into the combined serotonin/noradrenaline uptake inhibitors for your condition. I think Mirtazapine (Remeron) fits into this category. Here is a brief description of it:
Mirtazapine increases the release of norepinephrine from central noradrenergic neurons by blocking the presynaptic inhibitory alpha-2 autoreceptors. It spares the alpha-1 postsynaptic receptor and therefore results in a net increase in norandrenergic transmission. It mildly stimulates the 5-HT1A receptor while blocking the 5-HT2 and 5-HT3 receptors.
You ask me whether amisulpride or another dopaminergic AD will help get your HPA axis back to normal. I don’t remember reading of anything that mentioned that, so I guess not. I have read that high cortisol levels will downregulate the brain alpha 2-adrenoceptors, but in the longterm these receptors will upregulate in response to high cortisol.
Best wishes,
AndrewB
poster:AndrewB
thread:43509
URL: http://www.dr-bob.org/babble/20000822/msgs/44039.html