Posted by stjames on August 22, 2000, at 1:43:41
In reply to Re: Translation please, SLS » dj, posted by Cam W. on August 22, 2000, at 0:42:15
> > > I believe this new preparation consists of one of the fluoxetine stereoisomers rather than a >racemate.
> >
> >
> > ???? huh ????
>
> dj - It's like your two hands. They are basically mirror images of each other, like Scott said. - CamJames here....
Isomers have the same number of atoms (or number of fingers) but arranged the oppsite
way. Isomers can have differing, no action, or same action as each other. generally
organic life seems to prefer the d isomer, but this is not a hard fast rule. Some meds
contain stereo(both) isomers or just one isomer. Patents are very specific so each isomer
can be a different patent. This is the so called "least patentable difference", the smallest
change from a patented med needed to get a new patent.It is much cheaper to modify an existing med than to make on from scratch, Like Porzac of Effexor.
Big costs happen when you make sucessful novel meds. The original sucessful AD, Tofranil, a TCA,
was developed from sedating antihistamines like Benedryl. Tofranil then spawned many other TCA's, each
slightly different from the original atomic sturcture. I suspect that Prozac was released as the more sucessful
isomer with its other isomer held in the wings till needed. i would wait till after the pre marketing
studies are done to see how the real population responds. It is safe to say at least a few people will
do better on the new isomer but the real question is as a whole is this any better than Prozac or other AD's.
james
poster:stjames
thread:43425
URL: http://www.dr-bob.org/babble/20000811/msgs/43501.html