Posted by michael on August 18, 2000, at 17:18:38
In reply to Re: adrafinil,sulpiride/amisulpride,update Jensen, posted by JohnL on August 18, 2000, at 5:39:41
John -
Thanks for the reply. FWIW, I think (if I've understood correctly, and recall correctly) that amisulpride is a dopamine agonist at low doses (25mg, 50mg, maybe up to 100mg?), and an antagonist (ie: antipsychotic characteristics) at higher doses.
The lower doses are used to treat the negative symptoms of psychosis, which sound (at least to me) to be very similar to the anhedonic/dysthymic symptoms... The positive symptoms of psychosis are treated with much higher doses - don't recall the numbers off the top of my head (possibly something like 800mg - 1,200mg? - or that may be the doses of sulpride used to treat positive symptoms....).
I think. Anyway...
I believe sulpiride behaves the same way (except that it's a dopamine agonist up to 200mg/day - I think). Maybe Andrew or Scott or Cam, etc. can confirm/deny or shed further light...?
Also, I'm already a convert re: dr. jensen's methods. Still looking for the right combo for me, but if a med makes me worse, I move on, rather than try to endure until my body can tolerate it... just seems to make sense. Hope I and others have as much success as you have. (9 out of 10, wow, good deal! congratulations.) >Michael,
>
> I am not familiar with Sulpiride. I have heard from others that it is similar to Amisulpride, but that it is distinctly different as well. They are different enough that one may work when the other doesn't.
>
> I don't know about adding Bromocriptine either. I don't understand agonism/antagonism theories well enough to make sense of it. For example, on one hand Amisulpride is a dopamine antagonist. On the other hand, Bromo is a dopamine agonist. Would they cancel each other out? Would they instead act synergistically somehow? I don't know. I have some Bromocriptine but have never tried it. I think self-experimentation would be the only way to answer your questions. Very good questions at that.
>
poster:michael
thread:42846
URL: http://www.dr-bob.org/babble/20000811/msgs/43255.html