Posted by Kath on July 12, 2000, at 20:48:02
In reply to Re: F I N I S H = SRI Withdrawal Symptoms, posted by Sunnely on July 12, 2000, at 20:25:46
> > Thanks for this Sunnely - Are SRI's the same as SSRI's??
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> ANSWER: SRIs are not exactly the same as SSRIs. All SSRIs are SRIs but not all SRIs are SSRIs. (Did I get you more confused?) SRIs stand for serotonin reuptake inhibitors which include all antidepressant with serotonin effects. SRIs, therefore, include all the SSRIs (selective serotonin reuptake inhibitors) such as Prozac, Zoloft, Paxil, Luvox, and Celexa); the nonSSRIs such as Effexor which is both serotonin-booster (at lower doses) and norepinephrine-booster (at higher doses), and Serzone which is a serotonin booster with concomitant blocking effect on one of the serotonin receptor subtype called 5HT2 (reduces sexual disturbances). Technically speaking, Remeron is not an SRI even though it boosts serotonin (and norepinephrine) because it boosts these brain chemicals via a different mechanism, not through serotonin reuptake inhibition. However, the result is the same and serotonin withdrawal can also occur with this drug. BTW, Remeron also blocks the action of 2 subtypes of serotonin receptors 5HT2 and 5HT3, reducing sexual disturbances and gastrointestinal distress, respectively. Clomipramine (Anafranil) is also an SRI since it has serotonin effect and a tricyclic antidepressant, to boot.
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> Wellbutrin (and Zyban) is not an SRI because its antidepressant action is said to be due to NOREPINEPHRINE and DOPAMINE reuptake inhibition. This makes it a norepinephrine- and dopamine-booster. Reboxetine (Vestra, Edronax) is not an SRI because its main antidepressant action is due to its selective NOREPINEPHRINE reuptake inhibition.
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> A bit clearer?Wow - I'll have to print this off and read it VERY SLOWLY!!! Thanks very much. It'll take some slow concentration to get it absorbed. How in the heck do they know which med to give people. Is this why sometimes people have to try so many?
Thanks alot. Kath
poster:Kath
thread:40124
URL: http://www.dr-bob.org/babble/20000708/msgs/40246.html