Posted by shellie on July 6, 2000, at 19:16:48
In reply to Re: adrafinil-JohnL and everyone » shellie, posted by SLS on July 6, 2000, at 16:18:10
> If the MAO inhibitor is Nardil, perhaps she is concerned about the added stress this drug would place upon the liver. Parnate would not be a concern in this regard.
> - Scott
Hi Scott. I think my pdoc was not comfortable with adrafinil because it is a stimulant with both dopamine and seratonine release--giving the possiblity of both the dangerous high blood pressure rise, and also the general lowering of blood pressure. She also said there was a higher incidence of liver disfunction with this medication in general. The later doesn't bother me because I would just get liver function tests. But so far I am ambivelent about risking the blood pressure thing. And I think she's reluctant to recommend a combination that she's never seen before and that doesn't look good chemically to her.I would love to see more information about its use in France, i.e., how long it's been used, how often, and if ever with MAOIs. I haven't totally counted it out for the future, because I have eaten everything on the no list for maois in the last twenty years and was even given demerol during a hospital procedure with no bad effects, so I sort of think I don't get the high blood pressure thing. I have had it really dip--when I took serzone and nardil, I felt like I was high, and very airy and light, because my blood pressure was so low. But I also was getting too dizzy.
Second day off provigal, I am definitely more depressed and still tired. She said she thought it would take about three days to get out of my system. I am feeling very disappointed about the provigal side effect for me, and also the fact that she doesn't want me to go on adrafinil. (I am also worried about the tiredness--what if I have chronic fatigue syndrome or something. But she thinks it was probably the provigil.)
Next for me is ridalin with nardil, which is also a bit risky, but my pdoc is more comfortable because she has used them together before.
Good luck in what you decide. I'd recommend again that you try the provigil first, because you have the prescription and it presents the lesser risk. Let me know what you decide. Maybe you could get a second opinion from another pdoc. shellie
poster:shellie
thread:39515
URL: http://www.dr-bob.org/babble/20000630/msgs/39598.html