Posted by Cam W. on July 6, 2000, at 14:44:07
In reply to Cam - Zofran?, posted by Greg on July 6, 2000, at 11:06:12
Greg - I believe that Zofran is a selective serotonin-3 (5HT-3) antagonist. 5HT-3 receptors are mainly found in the small intestine (and in the CNS to a lesser degree). By blocking this receptor you decrease the nausea. The 5HT-3 receptor is responsible for the nausea seen as a start-up side effect of the SSRIs. Stimulation of the 5HT-3 receptor by the increased serotonin (as a result of the SSRI) causes nausea, which is resolved when this receptor is desensitized (usually within the first month after starting the SSRI). They use Zofran a lot after chemotherapy.
(If you want to have a little fun, ask your doc for Marinol for nausea. It is synthetic THC and has been described as smoking 100 joints at a time. The only problem with it is that it is terribly disorienting and doesn't work as well as Zofran. I thought that I would add this because you expect it from me). - Cam
poster:Cam W.
thread:39559
URL: http://www.dr-bob.org/babble/20000630/msgs/39572.html