Posted by SLS on July 4, 2000, at 8:25:38
In reply to Re: Availability of reboxetineAdrafinil in Australia?, posted by JohnL on July 4, 2000, at 6:09:04
> Though both drugs work on the adrenergic chemistries of depression, they do so in very different ways. For example, Reboxetine sent me into a rapid dysphoric depression. Because Adrafinil works on similar chemistries, I didn't expect it would be a good choice. It turned out to be a miracle. They are very different medications. Obviously I personally prefer Adrafinil. :-) More effective with hardly any side effects. Reboxetine could have more pronounced side effects.
> JohnL
I would strenuously like to emphasize that adrafinil does NOT act upon adrenergic alpha-1 receptors. A friend of mine spoke to the inventor of *adrafinil* at a conference several years ago. The inventor stated that he was *sure* that it did not antagonize NE alpha-1 receptors, and that the early work on this drug was wrong.I have not seen any evidence that either modafinil or adrafinil directly affect NE neurotransmission in any way. This might help to explain why you responded so differently to adrafinil versus reboxetine. That you also had a negative response to Wellbutrin, a drug which most researchers believe to exert a pro-adrenergic effect, might support the idea that your response to adrafinil is not NE-mediated.
Why is this important? At this point, I do not believe that inferences should be drawn as to how someone will respond to adrafinil based upon their experiences with noradrenergic drugs and vice-versa.
- Scott
poster:SLS
thread:39047
URL: http://www.dr-bob.org/babble/20000630/msgs/39314.html