Posted by SLS on June 29, 2000, at 8:21:03
In reply to Question for Andrew B, posted by Scott on June 24, 2000, at 3:34:58
Hi Scott, Andrew, and All Others
> > It is my obligation as a curious individual to ask you, basically, How are you so sure that Naphazoline is such an accurate "predictor" of response to Adrafinil (and I must assume Modafinil as well) and Reboxetine?
> I think my post is quite clear that the use of Naphazoline, an alpha andrenergic agonist, as a diagnostic tool to determine if adrafinil or reboxetine will be effective is something that I have concluded rather than a standard accepted and proven practice.
The idea of using naphazoline as a probe to help choose drugs for treating depression is intriguing. I have been looking at modafinil (Provigil) and some of its properties. I think it has been well established that Provigil is not a NE alpha-1 or alpha-2 agonist. I haven't been able to find any detailed information about adrafinil, as there aren't any applicable studies of its pharmacology appearing on Medline. If the same mistakes were made studying adrafinil as were made with modafinil, then it is probably not an alpha adrenergic agonist either. If response to naphazoline is a predictor of response to adrafinil or modafinil, it would not be because they share similar mechanisms of action with regard to NE alpha receptor stimulation.I think Scott's caveats are well taken. I can't wait to see if naphazoline challenges are valuable for treatment selection. However, it must be verified empirically. In the meantime, if one does not respond to naphazoline, I would recommend that they not exclude trying any drug based upon their non-response.
Has anyone responded well to an antidepressant that they chose based upon a positive response to naphazoline?If so...
1. What is your diagnosis?
2. What naphazoline preparation did you use?
3. How did you use it?
4. Can you descibe in detail how you responded to it?
5. What drugs were you taking at the time of the naphazoline test?
5. Which drugs did you choose based on your response to naphazoline, and how well did you respond to them.
6. What other drugs were you taking when you responded to the chosen drugs?
7. What drugs had you tried in the past, and how did you respond to them, positively and negatively?Thanks for any replies.
- Scott
poster:SLS
thread:36854
URL: http://www.dr-bob.org/babble/20000619/msgs/38679.html