Posted by AndrewB on June 24, 2000, at 9:41:12
In reply to Re: Pramipexole (Mirapex) For Depression » verac, posted by Jonathan on June 24, 2000, at 1:27:23
I've taken both pramipexole (Mirapex) and amisulpride. I have a combo of dysthymia, social anxiety, and some variant of Chronic Fatigue. The amisulpride was effective in removing the greater proportion of my dysthymia, my social anxiety and my chronic fatigue. Amisulpride kicks in and starts working for me in only 4 days. For more information on amisulpride and how to obtain it, email me at andrewb@seanet.com for an information piece.
Pramipexole was not effective for me however. Which is curious since pramipexole is very similar in action to amisulpride. Both act specifically on the D2-D3 receptors. The amisulpride antagonizes the presynaptic receptors while Mirapex is a postsynaptic agonist. Possibly, others are like me. They respond very well to one of these meds but not the other.
Pramipexole is only available, I believe, in the US and Canada with a prescription. Requip though is available in Britain and many other countries and appears to have an D3/D3 agonist action much like pramipexole and it has been suggested that it may have a similar antidepressant potential to pramipexole.
AndrewB
poster:AndrewB
thread:11831
URL: http://www.dr-bob.org/babble/20000619/msgs/38244.html