Posted by SLS on June 17, 2000, at 9:46:25
In reply to Re: Parnate and Adrafanil?, posted by JohnL on June 16, 2000, at 18:43:10
> Andrew mentioned that he thought Adrafinil had worked on my anhedonia. Definitely. Absolutely. Completely. No ifs, and, or buts about it. The list of previous meds is staggering.
>
> We often think of dopamine as the pleasure center, and focus on dopamine for anhedonic type symptoms and such. But I am living proof that the norepinephrine system is just as powerful a pleasure center as dopamine is, if not more so.
>
> But yes, Adrafinil completely wiped out a loonnnggg stubborn depression marked by prominent anhedonia.
> JohnL
John - I am still curious if you have decided to return to adrafinil. Did Provigil act upon anhedonia at all? Besides the headaches, what was it about Provigil that you found inferior to adrafinil? Was there a tendency for the positive effects of Provigil to dissipate? You did report a remarkably positive effect from it initially. What dosage did you work up to? Did you find that Provigil exhibited the same biphasic response curve as does adrafinil?I would be grateful for any input. If sulpiride does not prove helpful to me, I would probably want to try adding Provigil or adrafinil to Parnate at some point.
Thanks.
- Scott
poster:SLS
thread:37287
URL: http://www.dr-bob.org/babble/20000610/msgs/37630.html