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Re: Amisulpride, Peter S

Posted by AndrewB on June 3, 2000, at 8:46:29

In reply to Re: Michael, follow up Qs, posted by Peter S. on June 2, 2000, at 20:14:01

Peter,

Your diagnosis of dysthymia and social phobia indicates dopaminergic D2-3 hypofunction. A recent study indicated low D2 receptor binding potentials in social phobia. Nardil has long thought to be effective for social phobia due to its dopaminergic action. Therefore one would think that the D2-3 dapaminergic activity enhancing amisulpride would be a drug that you would be responsive to. But this obviously wasn't the case. All you experienced was sleepiness. Michael experienced the same thing at 50mg. Sleepiness indicates that one is taking too much amisulpride and the postsynaptic, rather than the targeted presynaptic D2-3 receptors, are being stimulated. Intuitively the solution would be to lower the dose. Michael has done this, lowered his dose to 12.5 mgs., with some initially promising results. You may therfore wish to retry amisulpride at a lower dose (such as 25mgs) as an augmenting agent to nardil. Let me know if you find this effective. Indeed, if you are able to find effective dopaminergic augmenting agents for Nardil (like amisulpride), you should be able to lower the effective dose of nardil and thus lower your side effects.

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URL: http://www.dr-bob.org/babble/20000603/msgs/35826.html