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Re: Good Luck !!! » AndrewB

Posted by SLS on June 2, 2000, at 17:41:40

In reply to Re: SLS, posted by AndrewB on June 1, 2000, at 12:33:53

> BTW Scott, the more I read, the more I think your adverse reaction to rebox. was due toNE stimulation other than that of the alpha 1 andrenergic receptor.

I agree with you. Beta - anxiety vs propanolol.

I would really like to know what you found that steered you in this direction.

> This would mean adrafinil should not cause the nasty depression and anxiety in you, but would have the potential to help relieve your fatigue.

This is razor-sharp. Thank you.

> I've found St. Johns to be pleasently uplifting. Trying entacapone, the COMT inhibitor, now.

I imagine you've already checked out compatibility. It looks pretty safe to me.

I double-checked:

There doesn't seem to be any untoward autonomic effects when entacapone is added to l-dopa, imipramine, desipramine, deprenyl, or moclobemide. I thought these combinations might equate with the actions of St. John's Wort as you have described them.

Entacapone seems to exaggerate the cardiac effects of stimulants, bronchodilators, adrenalines, and other sympathomimetics; it increases heart rate and blood pressure. However, I don't know enough about St. John's Wort to speculate if any such reaction would be potentiated by it. Entacapone accelerates the excretion of sodium. I can't comment on the degree or significance of any of this.

Good luck, pal. I just prayed for you. I hope you don't mind. :-)


- Scott

 

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