Posted by michael on May 31, 2000, at 20:10:25
In reply to Re: Amisulpride and Selegiline, posted by AndrewB on May 31, 2000, at 17:54:15
Hey Andrew -
As always, thanks for the input...
And as for wellbutrin, never did much for me, except help w/smoking - even at 400mgSR/day. I may have gotten a little boost from it temporarily, which passed quickly, or it may have just been a placebo type of thing... it was a couple years ago. I've been on it roughly a month now.
This time it made me a bit edgy for a while, which I attribute to the fact that I went up to 400mgSR/day so quickly, which I did because from my previous experience, I knew I need to go that high (I was taking 300mg before I took my 2 week break), and that I had essentially no side effects in the past - except, now that I think back, I believe it increased my libido some. No apparent problems, so far, with the adrafinil/wellbutrin combo.
I tried St. John's before I tried wellbutrin - no effect that I could notice. I'll be interested to hear about your experiments/trials.
One more item, re: the adrafinil... It may not have faded after just the first week - I was really clobbered by that cold during weeks 2 & 3, and I don't think I would've noticed any difference - but I wanted to continue, since the effect is supposed to be cumulative - or at least vary as time goes by. That's also roughly the time I started again w/the wellbutrin... so I thought that may have been a factor as well...? Too many variables already.
Just for the record - I do know of at least one other person who claims it faded on them after a week, during which they noticed a significant improvement... Who knows - the YMMV motto is the only aboslute w/this stuff.
I'll let you know what I come up with, with the amisulpride and selegiline... That's it for the moment... michael
>
> Michael,
>
> It sounds like you are taking a reasonable approach with your drug trials. One at a time is definitely the way to go.
>
> Tell me how did you respond to Wellbutrin before? Did it increase your energy? Did it give you side effects?
>
> Be careful when combining Wellbutrin and Adrafinil. Both work on NE. For example if you add a full dose of Wellbutrin to an already significant dose of Adrafinil, you might find yourself over agitated and with a rapid pulse and high blood pressure when the Wellbutrin fully kicks in.
>
> If you haven’t experienced increased arousal either with Wellbutrin alone or this combo of Wellbutrin and Adrafinil, you may not be responsive to NE meds.
>
> You can try a higher dose of Adrafinil, but only after you’ve given your system time (2 weeks) to stabilize on Wellbutrin. Also make sure your pulse and BP is not excessive.
>
> Adrafinil receptors shouldn’t become tolerant after a week. I don’t think NE tolerance can work that fast. Sometimes though the increased energy might last only a week if there is an underlying metabolic insufficiency.
>
> With the amisulpride I suggest that, yes, you do another 12.5 mg. trial for a week. If all goes well then do a 25mg. trial for a week. Hopefully this dose will give you a fuller response without the sleepiness. If this goes well you can try a 37.5mg. dose.
>
> I reviewed some literature and I think that your idea of augmenting with selegiline is worth a try. You may experience increased energy and mood at a dose of 5 to 15 mg. I forget how long the effect takes to kick in. Again, don’t do this trial until you have stopped fiddling with the other meds.
>
> Phenylalanine sometimes can be added onto selegiline with good results. I would give it a try. The trial need only take four days and it is available at the health food store.
>
> St. John’s Wort also has some dopamine inhibition. I like what it has done for me. It seems to be gently uplifting of energy and mood.
>
> Please let me know how it goes with your amisulpride trials and your selegiline augmentation.
>
> Do you have a couple of favorite international pharmacies that you haven't already told me about. If so, drop me a line. I'm going to put together a list. Of course, non prescript. sources are of the most interest.
>
> Best wishes,
>
> AndrewB
poster:michael
thread:34862
URL: http://www.dr-bob.org/babble/20000526/msgs/35436.html