Posted by Cam W. on May 18, 2000, at 19:03:26
In reply to Re: SSRIs: - Different, posted by SLS on May 18, 2000, at 7:44:41
Scott - I totally agree with you that it depends on the presentation of the depression as to which AD to try second. Many times one SSRI will work when another hasn't. To bad no systematic evalutions or guidelines have been done or are available. Any grad students looking for a project?Scott, the Johns, Elizabeth, bob, Dr.Bob and any other techno-pharmageek (like me) that I may have missed.
You people might be interested in an article I downloaded from Neuroscion (http:neuroscion.com). They give you six months or 30 articles to download. It is really a technical "geek" site; very in depth articles (the kind we like - COMT inhibitors, CRH antagonists, etc.).
Articles with names like, "On the design of neural networks in the brain by genetic evolution" or "Cannabinoids inhibit excitatory neurotransmissions in the substantia nigra pars reticulata" or "Serotonergic neurons and serotonergic receptors: gains from cytochemical approaches" or "Novel brain function: biosynthesis and actions of neurosteroids in neurons" or "Multiple substrates for seotonergic modulation of rat locus coeruleus neurons and relationships with kainite receptors" or "In vivo NMDA/dopamine interaction resulting in Fos productin in the limbic system and the basal ganglia of the mouse brain." I think you get the picture.
An article that you MUST read is in a journal called Brain Research Bulletin entitled:
"The specificity of stress responses to different nocuous stimuli: neurosteroids and depression" by someone out of McGill University by the name of B.Dubrovsky. It is an excellent article on man's thoughts on stress and depression from Plato through the existentialists to present day. A fantastic article (easy to read, too).
poster:Cam W.
thread:33808
URL: http://www.dr-bob.org/babble/20000517/msgs/33947.html