Posted by SLS on May 18, 2000, at 10:34:09
In reply to Risperidone and Serzone and Anger (oh my), posted by CraigF on May 17, 2000, at 19:24:51
> Do these things go away? if not, Is Risperidone helpful at .5 mgs? Just Serzone is NOT. My life is starting to fall into shambles. I'm either reclused and scared or losing my temper. This is worse than me pre-medicated.
>
> HELP!!!
>
> PS -- I am being treated for depression and anxiety. The Risp is an adjunct...I am not Schizophrenic.
I bet your anger and state of frustration appear as a result of the drop in blood (and brain) level of Risperidone, as its half-life is only about 6 hours. Perhaps more frequent dosing would help. An alternative would be to use a neuroleptic with a longer half-life. Zyprexa has a half-life of about 35 hours.I get the feeling that Zyprexa offers a greater potential to exert an antidepressant effect. Currently, there are investigations evaluating the efficacy of combining Zyprexa with an SSRI to treat depression.
I hope you can resolve this situation using one of the suggestions you find here. If you are convinced that risperidone is helpful, I would stick with using one of three neuroleptics: Zyprexa, Seroquel, or Risperdal.
Serzone sounds like it may be hurting you more than it is helping. Your doctor is probably right about the metabolite, mCPP, causing some problems. It can be really nasty sometimes. It may be that Risperdal masks the mCPP-induced anger. As the level of Risperdal ebbs between dosing, this anger might may be uncovered.
Good luck.
- Scott
poster:SLS
thread:32301
URL: http://www.dr-bob.org/babble/20000517/msgs/33885.html