Posted by PeterJ on May 16, 2000, at 19:18:24
In reply to Serotonin Response??, posted by AndrewB on May 16, 2000, at 10:30:24
> I took Serzone for 7 months and never felt anything but fatigued, foggy headed, and emotionally numbed. My mood never improved, from low to high doses. Does that indicate other serotenergic ADs also would not change my mood. Why do some serotenergic ADs, but not all, give some but not all people these side effects?
Serzone has a very complex constellation of biochemical effects. It is a mild uptake
inibitor for serotonin but it also blocks post-synaptic 5-HT2 serotonergic receptors.
It has a metabolite, mCPP which is very active as a serotonin agonist and has
pronounced noradrenergic effects. Serzone itself also has some noradrenergic effects.Trazadone is related to Serzone and also has many complex effects. It is usually more
sedative than Serzone.This complex mix of activities is not shared with most other serotonergic drugs. Most
SSRIs in particular, by definition, primarily inhibit serotonin uptake only. Thus one
definitely cannot predict response to an SSRI from one's response to Serzone. They are
too different.I say this not only based on biochemistry but on observation. I have known individuals
who responded very poorly to Serzone or Trazodone, but nonetheless responded well to an SSRI.
The reverse also happens: good response to Serzone or Trazodone and bad response to an SSRI.SSRIs would include Prozac (Fluoxetine), Luvox (Fluvoxamine), Paxil (Paroxetine), Celexa
(Citlopram), and Zoloft (Sertraline). Effexor is an SNRI (Serotonin-Norepinephrine uptake
inhibitor.) Remeron (Miratzepine) has both serotonergic and adrenergic effects, but it is
not primarily an uptake inhibitor.Peter
poster:PeterJ
thread:33608
URL: http://www.dr-bob.org/babble/20000508/msgs/33695.html