Posted by AndrewB on May 5, 2000, at 17:23:26
In reply to Re: Amisulpride + Vivactal, posted by anita on May 5, 2000, at 13:44:57
Anita,
I’m sorry. I forgot what you had told me before about your amisulpride experience.
I agree with you that it would be a good idea to write a post summing up peoples' experiences with amisulpride. The problem is that feedback is real limited so far. I am filing peoples' responses and hopefully there will be enough feedback in a couple of months to write such a post.
The side effects of weight gain and altered menses can be eliminated by restoring normal prolactin levels. This can be accomplished by taking bromocriptine or Mirapex (pramipexole).
The irritability I don't think would be effected by changing the prolactin levels. That has something to do with over stimulation or excessive dopamine levels wouldn't you think? It is interesting that you got this effect with such a low dose. I've got a couple of suggestions as to how to avoid the irritability but they are really just shots in the dark.
One would be to pulse dose the amisulpride in order to give your body a break. Maybe one day on and one off or 5 on and 2 off.You also may want to try Mirapex. It is different from other dopaminergic medicines. For example, it has much greater affinity for the D3 receptor than amisulpride and, conversely, a smaller affinity for the D2 receptor than amisulpride. It has been speculated that it may be most effective for atypical depression and supposedly it is going to be studied for use with bipolars. There seems to be a continuing interest in it for use as an Antidepressant, alone or as an adjunct. The latest study on it just came out last month. But I've never tried it by itself and have heard only one other persons experience with it so I can’t really say too much about it. I'm going to try it by itself, that is, without amisulpride, in this upcoming week to see how strong its AD effect is. Anyway, I know you are looking for the right dopaminergic, maybe Mirapex is it.
Best wishes,
Andrew
poster:AndrewB
thread:32182
URL: http://www.dr-bob.org/babble/20000429/msgs/32451.html