Posted by Judy on May 3, 2000, at 20:49:24
In reply to Re: Parnate+Selegeline Temptation, posted by Adam on May 3, 2000, at 0:28:23
Hey Adam
Thanks for coming our of lurkdom to respond. And thanks for not completely burstng my bubble. I realize how highly contraindicated combining two MAOI's is. After two readings of your message, I'm still not sure I'm ready to ignore my gut feeling that I'm on to something here, particularly after reading Anthony's message.
Let me try to explain a bit more. I've many times experienced that 'honeymoon' that occurs with the lessening of side effects while the AD effect is still in place when you quit a drug. But it usually lasts for a day or so when you say to yourself, "Geez, maybe I made a mistake, I feel pretty good on this stuff." What I felt for at least two weeks was exactly what you wrote about when you started the patch. That galloping joy that you can't really harness but it's wonderful anyway. You don't sleep, but you don't need it; you'll talk about anything at a million miles an hour to anyone, even strangers in the street. That lasted a day or two and then I settled into a blissful state of focus, motivation and energy that enabled me to paint my 13' high kitchen ceiling and then feel pleasure and accomplishment when it was done. (Just like I would have felt on Nardil, might I add). This was NOT lessening of side effects - I didn't have any with Selegiline!
You mentioned the similarities in structure of Parnate and Selegiline. At low doses of both, wouldn't that tend to work in my favor? What exactly might be the physical risks in combining the two? Hypertension? I had notable postural hypertension with Nadil, but not with these two; however, that's not to say that combining them wouldn't cause it. If they are stimulants, it wasn't obvious physically - in fact Parnate tends to make me 'nod' unless I space out the dosage correctly; again, who knows about combining the two? What else? I keep thinking of all the elderly Parkinson's patients who take Selegiline and imagine all the other medication they're probably pumping into themselves...
I have taken lithium alone before. It was a horrendous experience - made me suicidally sedated; but I did consider trying it with Parnate (perhaps I had that in mind from one of Elizabeth's old threads) before I got this bee in my bonnet.
Right now 60 mg of Parnate is allowing me to cope but I'm so, so tired of the anhedonia. I have two daughters graduating this year and I would love to stand there and cry tears of joy and feel their accomplishments at the ceremonies. I know I'll cry - but it won't be the same. In fact, I'll make a deal with you - if you'll call the doctor Anthony mentioned and he even touches on the positive, I'll gladly be the guinea pig!
Judy
poster:Judy
thread:31946
URL: http://www.dr-bob.org/babble/20000429/msgs/32142.html