Posted by Scott L. Schofield on April 28, 2000, at 20:24:51
In reply to Substance P antagonist antidepressant??, posted by Andy on April 27, 2000, at 18:15:59
> I just read about this drug in development and it has shown promise for treating the above and anxiety disorders. I'd like to know someone can try this and other drugs in development without going to a clinical trial center. There they want you to stop all meds before trying the studied drug. I've been taking ativan for years and cannot stop.
How recent is the information you have encountered?Last year, there was quite a bit of excitement surrounding the possible efficacy of substance-P antagonists as antidepressants. I think this was brought about by the conclusions reached by a single study. There may have been others, but I remember this one in particular garnering all of the attention. Subsequent studies published a few months later contradicted these conclusions. I checked out Medline to see what's happening. It seems that the substance P preferring NK1 receptor remains an object of study for the development of antidepressants.
It's hard to find open-label studies of investigational drugs.
- Scott
poster:Scott L. Schofield
thread:31516
URL: http://www.dr-bob.org/babble/20000420/msgs/31617.html