Posted by Cam W. on April 11, 2000, at 19:07:25
In reply to Re: Fentanyl patch and buprenorphine (Cam W.?), posted by Greg on April 11, 2000, at 14:09:18
Nigel - Buprenorphine is not used in Canada and I really do not know much about it. I think it is a synthetic opiate being tried in combination with naltrexone for treating opiate addiction (in France). I think it is a mixed agonist (mu receptor)/antagonist (kappa receptor) and naltrexone is a mu antagonist, thus leaving you with a kappa receptor antagonist, similar in action to methadone. Studies have shown that it doesn't work as good in maintenance therapy as methadone. By itself, it was supposed to elicit euphoria like morphine. Also, in combination with benzodiazepines it has caused respiratory depression and death in a number of people in Europe. Also, both fluvoxamine and fluoxetine inhibit it's metabolism.The above I gleaned from abstracts on MEDLINE, but other than that, I really don't know what it is good for. - Cam W.
poster:Cam W.
thread:29627
URL: http://www.dr-bob.org/babble/20000411/msgs/29659.html