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Re: Question for AndrewB....

Posted by AndrewB on March 27, 2000, at 9:33:32

In reply to Re: Question for AndrewB...., posted by JohnL on March 27, 2000, at 4:30:19

> Andrew, I'm confused. Amisulpride is a D2/D3 antagonist. But Mirapex is a D2/D3 agonist, right? Aren't these drugs counteracting each other? You know the chemistries involved a whole lot better than I do, so I was just wondering how these two could work synergistically? Your thoughts?
> Thanks. JohnL

At the low doses I take amisulpride it is a presynaptic receptor antagonist. More specifically, the amisulpride is blocking stimulation of the presynaptic autoreceptors which are part of a feedback loop that tells the presynaptic neuron to manufacture and produce less dopamine in response to the (excess) levels of dopamine in the synaptic cleft. The result is amisulpride, by blocking this feedback mechanism, enables excess dopamine to enter the synaptic cleft, causing more stimulation of the postsynaptic receptors. Meanwhile, Mirapex is mimicing dopamine and providing additional stimulation of the postsynaptic receptors.

AndrewB


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URL: http://www.dr-bob.org/babble/20000321/msgs/28230.html