Posted by Cam W. on March 23, 2000, at 20:42:02
In reply to Transient Blood Pressure Increase due to Serzone? , posted by Rick on March 23, 2000, at 14:34:10
Rick - Yes, Serzone does inhibit CYP-3A4 very potently and Nifedipine is metabolized by this enzyme ststem, therefore one would expect elevated Nifedipine blood levels. BUT, things are never this easy. Even though nifedipine is mainly hydroxlated by CYP-3A4 the genetic make up of your friend MAY offset the inhibition (ie his liver may produce plenty of enzyme to keep Nifedipine metabolism at normal levels - but this is unlikely). One would expect the increased blood levels of Procardia to cause hypotension.Does he get his Serzone and Procardia prescribed by the same doctor? If different doctors are prescribing, do they know of each other's existence?
Does he use the same pharmacy for all his medications? The computer should have flagged this interaction.
Serzone frequently causes hypotension, but infrequently can cause hypertension. The Serzone MAY have contributed to the increase in blood pressure.
My conclusions - I don't know for sure, but the above are educated guesses.
Hope this helps - Cam W.
poster:Cam W.
thread:27954
URL: http://www.dr-bob.org/babble/20000321/msgs/27977.html