Posted by JohnL on March 12, 2000, at 14:12:58
In reply to Reboxetine lamictal, posted by Stephanie on March 12, 2000, at 9:30:01
> Is there any information about taking the combination of reboxetine & lamictal for bi-polar?
At Depression Central Dr Ivan Goldberg says that Lamictal can be taken with MAO inhibitors. From that I would feel comfortable that Lamictal is safe with Reboxetine. The combination seems perfectly fine to me.
The one thing we don't know is how Reboxetine will affect Lamictal's metabolism. If it slows it down so that plasma levels are higher than expected, then you could run into the dreaded Lamictal rash. The safe way to approach Lamictal is by increasing dose 25mg per week. But with some other drugs that do affect its metabolism (like Depakote I think?), that has to be reduced to 12.5mg a week, since plasma levels are actually doubled. Since we don't know about metabolism with Reboxetine in the mix, it might be wise to play it safe and be on the conservative side of dosing. I take Lamictal. If I was to add another drug that I wasn't sure of, that's what I would do.
poster:JohnL
thread:26758
URL: http://www.dr-bob.org/babble/20000312/msgs/26766.html