Posted by JohnL on March 10, 2000, at 3:30:12
In reply to Re: Help! Vitamin B-12 induces severe depression , posted by MJ00 on March 9, 2000, at 0:55:53
That's an interesting and puzzling observation. I've always heard that B12 and folate are often deficient in depression. I know one lady who's depression only responded to three injections per week of super megadose B12. (Not just supplements, but actual injections!)
But our chemistries are all so different. Anything's possible. I wish there was an easy answer for you. And me, for that matter!
This is just a gut instinct, but with a dopamine connection either an antipsychotic (Zyprexa, Stelazine, or Risperdal) and/or a stimulant (Ritalin, Adderall, Dexedrine, Tenuate, Ionamin) might be considered. The combination often works very well when antidepressants don't. Tenuate by the way closely resembles Wellbutrin in molecular structure, but sometimes works much better. It is a prescrip diet med. Of this class of meds, I've heard the most anecdotal success with Adderall in depression/anhedonia. But one of the others could just as well be the molecule your chemistry likes the best.
I think a stimulant would be the first place to look, since they work so fast when they work. Anywhere from the first day to four. If one doesn't cut the mustard in a couple days, move quickly to the next. One of them might get to the heart of the problem that's causing your symptoms. A tiny dose of an antipsychotic can smooth it out nicely. Zyprexa 2.5mg would be excellent for that as well as sleep. Just some ideas that I think have a high probability of working with you.
poster:JohnL
thread:494
URL: http://www.dr-bob.org/babble/20000302/msgs/26572.html