Posted by bob on March 7, 2000, at 17:25:54
In reply to Re: effexor dosage effects, posted by michael on March 7, 2000, at 16:30:28
According to the Manual of Clinical Psychopharmacology, venlafaxine (damn book won't index drugs by their brand names, grrrrrrrrr) works primarily on seratonin with "moderate effects" on norepinephrine as well. Nothing in there about needing to hit a certain dosage to get the NE effects to kick in. It *does*, however, point out that "most depressed outpatients" respond to it in the 75-225 mg range, while refractory or melacholic depressives may need to go up to 375 mg.
The Handbook of Essential Psychopharmacology, on the other hand, lists effexor (cross-referenced to venlafaxine in its index =^) as having "marked effects" on seratonin, "moderate effects" on NE, and "modest effects" on dopamine, but only at higher levels.
So, putting the two together, I'd bet the story is that the dopamine effects kick in above 200mg, but you get the other two at any level.
bob
poster:bob
thread:26198
URL: http://www.dr-bob.org/babble/20000302/msgs/26276.html