Posted by Cam W. on February 29, 2000, at 22:43:54
In reply to Re: Cam , what are benzos???, posted by saint james on February 29, 2000, at 21:51:42
James - Although clonazepam (Klonipin or Rivotril in Canada) has a half-life (no active metabolites) that varies person to person (18-80h), it is still considered an intermediate-acting benzodiazepine. You could probably say it is at the cusp. Long-acting benzos include: chlordiazepoxide, diazepam, chlorazepate (Tranxene), and flurazepam all having half-lifes (including active metabolites) in excess of 100h. Most have different end metabolites determined by their lipid solubility. Most undergo oxidation reactions while others primarily undergo conjugation (bromazepam - Lectopam, lorazepam, oxazepam, and temazepam) or nitro reduction: (clonazepam and nitrazepam). Incidentally, since oxidation reactions are reduced in the elderly, the benzos of choice in this group are the one's that undergo conjugation metabolism (which does not decrease with age) and have no active metabolites (lorazepam, oxazepam, and temazepam). Active and endpoint metabolites available upon request (too lazy to look them up) - Cam W.
poster:Cam W.
thread:24982
URL: http://www.dr-bob.org/babble/20000220/msgs/25016.html