Posted by JohnL on January 7, 2000, at 12:35:33
In reply to Nortriptyline, posted by Andy on January 7, 2000, at 9:32:17
I'm glad you're having some improvement Andy. I sure want it to continue getting better for you. Good news.
Nortrip does have a therapeutic window. But when it's combined with another drug it's a whole different story. Prozac slows down the metabolism of Nortrip considerably. Thus larger amounts of Nortrip accumulate in your system. Buspar might also be involved. But I do know for sure that clinical studies have shown Prozac inhibits the metabolism of Nortrip in such a way that it (at a minimum) effectively doubles the dose. So your 25mg is actually about 50mg+, which is (a guesstimate) at lower end of the therapeutic window.
My GP's favorite antidepressant combination is any SSRI + Nortrip. But Prozac does slow the metabolism of Nortrip more than the other SSRIs, so careful dosing is warranted. But my GP swears by this combination. He gets all excited talking about it.
Anyway, that's probably why your 25mg is working as well as it is. I have no clue about the sense of smell thing, but that sounds pretty cool. Hey, wishing you continued progress. :) JohnL
poster:JohnL
thread:18283
URL: http://www.dr-bob.org/babble/20000101/msgs/18303.html