Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Parnate: weight gain, & the literature - Liz

Posted by Elizabeth on December 14, 1999, at 4:44:22

In reply to Re: Parnate: weight gain, & the literature - Liz, posted by Zeke on December 14, 1999, at 1:39:09

> > :-) Well I *did* say "AFAIK." You can't argue that I knew of documented weight gain with Parnate! :-)
> >
>
> You're a tough sell -- probably from Missouri -- but I respect that!

Not even close - Boston. :)

> General references like the PDR and the Merck Manual (and especially the watered down popular books) tend to generalize the MOAIs and use the same profile for all.

Yeah, I know. Among my many flames about such references. :)

> Well among other things, the DEA is keeping an eye on Parnate and its derivatives for abuse potential.

I guess they wonder about it too. There *have* been reports of that in the literature (and in people, too!).

> http://rhodium.lycaeum.org/chemistry/future_drugs.html

> (Interestingly, is the Surgeon General's report documenting people not seeking help for psychiatric disorders.

I can't find this...happen to have a URL?

>Gee guys, we take away the tools and what do you expect. We've already removed the promising application of MDMA in psychotherapy because of morally biased research.)

You know, I really don't think that opposing use oof certain types of drugs has anything to do with morality. Maybe that's just my own moral bias, though!

> IMHO Parnate is also mainly for refractory depression:
>
> "Tranylcypromine in high doses (20 to 30 mg po bid) is often effective for depression refractory to sequential trials of other antidepressants; it should be administered by physicians experienced in the use of MAOIs."
> --The Merck Manual

True, that's what I use MAOIs for (haven't given tricyclics an adequate trial due to side effects, though).

> > Uhh... "There are no cases of tranylcypromine-induced weight gain in the literature that are clearly associated with the drug." (This was after the drug had been approved in this country for nearly 30 years.)
>
> With emphasis on the word 'clearly.'

I think that's what I'd require to consider it real evidence that Parnate "causes" or "induces" weight gain.

> > No doubt the appetite reduction helps, though my appetite increased on Parnate (probably secondary to remission of depression!).
>
> Remember that increased appetite (especially carbo cravings) are a symptom of atypical depression, just as weight gain is!

Well yeah, I thought that was where the weight gain came from! Eating junk food, especially at night.

> You might find this one interesting
>
> Richard J. Wurtman and Juidith J. Wurtman
> Carbohydrates and Depression
> SCIENTIFIC AMERICAN January 1989
> http://www.sciam.com/0189issue/0189wurtman.html

Oh god, not the Wurtmans!


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Elizabeth thread:9748
URL: http://www.dr-bob.org/babble/19991212/msgs/16886.html