Posted by Elizabeth on July 21, 1999, at 23:49:39
In reply to Re: Answer to Elizabeth, posted by Annie on July 21, 1999, at 13:55:57
> Elizabeth, Thank you for the study info. I'm not certain that the tested 60mg taken orally would be sufficient for me since I am a "super- metabolizer", but I'll copy it for my Pdoc and see what he says.
Maybe it's just some general fast-metabolizer thing, but different drugs are metabolized through different pathways, so the high dose of desipramine you needed wouldn't necessarily mean you'd also need a high dose of selegiline (30mg isn't that high for depression).
> Yes, I do have an appetite on selegiline and I am eating normally. In my case, the loss of weight is greatly appreciated.
Cool!
> I never considered the lack of motivation and isolating features of my depression as related to anxiety. Interesting thought. Possible. I thought I could use a little amphetamine action to get myself going.
Well, sometimes anxiety makes people feel kind of "dead," easily fatigued, sluggish, etc., and I could see it sapping motivation as well.
> The selegiline study is still on-going in many parts of the country, so it may be quite a while before the final results are published. If I see any preliminary data, I will let you know. I know I saw one article published but it more Rah- Rah hype than scientific data.
Actually I know a fellow who was conducting the study at McLean, here in Boston - perhaps I'll enquire (I don't even know if it's still going on).
> I know the hard way that Desipramine was not the drug for me, I used that example because TCA levels can me measured and to illustrate the high dose I needed to get to therapeutic level. I have had many trials of SSRIs et al at high doses with similar (non)results.
Well, that might just mean that SSRIs don't work for you. Actually there have been attempts to come up with recommended serum levels for fluoxetine and norfluoxetine at least.
> Regarding the spontaneous hypertension, after only 3 days on Parnate at minimum dose, my BP went from 127/73 to 200/102.
Mine increased by about the same amount, only I had a much lower (~100/60) baseline BP so it didn't get as high (180/100?).
> I usually don't experience withdrawal symptoms during washout periods, but thanks for the advice. I'll have some Xanax ready just in case.
MAOIs can have pretty rough withdrawal symptoms - don't play fast and loose with them! There's also just the difficulty of no longer being on an antidepressant, though for just two weeks that shouldn't matter too much.
poster:Elizabeth
thread:5905
URL: http://www.dr-bob.org/babble/19991001/msgs/9059.html