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naltrexone for antidepressant augmentation

Posted by jd on September 21, 1999, at 15:16:10

Hi all,
Since there's been a lot of interest
on this board about it during the
last few months, thought I'd share an
case report I just saw about using
naltrexone as an augmentation strategy
in depression... It's one of the
first "official" things I've seen
in the literature, although what's
needed most is a double-blind study,
obviously. (See the "tips" part of
this website for more anecdotal reports
from Dr. Lee Dante and others, as well
as Wayne R.'s earlier posts about his
own very positive results. Wish I could
say mine were as good, but it does seem
promising for a lot of people with
chronic problems and/or "poop-out".)
Best,
JD

----
Amiaz, Revital; Stein, Orit; Dannon, Pinhas N.; Grunhaus, Leon; and others.
Resolution of treatment-refractory depression with naltrexone
augmentation of paroxetine: A case report.
Psychopharmacology, 1999 Apr, v143 (n4):433-434.
Pub type: Empirical Study; Clinical Case Report; Followup Study;
Treatment Outcome Study.

Abstract: Reports the case of a 57 yr old female affected by a prolonged,
non-remitting, treatment-resistant depressive state accompanied by somatic
complaints. Previous treatment trials with various antidepressants (some
of which were augmented with lithium of buspirone) brought only little
improvement and worsened her complaints due to a poor tolerance of side
effects. Her condition worsened after a short hospitalization for
dehydration during severe gastroenteritis and she was admitted to a
psychiatric ward. Diagnosis at admission confirmed major depression and an
axis II histrionic personality. She was discharged 4 mo later, after
cognitive group therapy, personal psychotherapy, and resuming paroxetine
treatment. 3 weeks later she was readmitted but refused electroconvulsive
therapy. Augmentation of 20 mg/d paroxetine with 50 mg/d naltrexone
resulted in complete alleviation of her depression beyond followup. This
suggests a potential new strategy for helping patients with
treatment-refractory depression. ((c) 1999 APA/PsycINFO, all rights
reserved).


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poster:jd thread:11854
URL: http://www.dr-bob.org/babble/19990914/msgs/11854.html