Posted by Rick on September 15, 1999, at 15:16:28
In reply to High Dose Selegiline (Deprenyl) for Social Phobia?, posted by John on September 9, 1999, at 12:10:53
Low-dose Selegiline was adding a nice, activating dimension to the Klonopin I take for Social Phobia. (I also take low-dose, Pindolol Beta Blocker for lowering hypertension/heart-rate, but I don't think it's reputed seratonergenic(sp) effect has any psychotropic effect on me, other than maybe causing a bit more fatigue and perhaps giving me worse dreams).
Oddly, and rather sadly, I had to drop the Selegeline because it was TOO effective in the sexual department. Klonopin already does a lot for me sex-wise, and adding the Selegeline I wentt "over the top"; I couldn't "perform" for more than a very short time without having an explosive orgasm. (Sorry about the explicitness, but this is real mediucine talk here.)
One more thought -- maybe it was the elimination of the Selegeline that got me back into my fammiliar and irritating nutty/nonstop dream mode, NOT the addition of the Beta Blocker.
Rick
----
> Hi,
>
> Anyone with experience with "high dose," 60 mg/day or greater, Selegiline (Deprenyl) for social phobia? My thinking is that it could be an alternative to Nardil and Parnate if taken as the higher doses where it loses its MAO-B selectivity (>10-15 mg/day). I've seen some threads on what I think is this site (the old RxQx) where practictioners mentioned using up to 60 mg/day of Selegiline in successfully treating depression. So the question: at this level, how does it compare to the "gold standard" Phenelzine? ANYONE WITH EXPERIENCE? By the way, I'd stick with Phenelzine if it didn't leave me with erectile dysfunction (at the slightest dose), anorgasmia (I guess that's secondary to erectile dysfunction - uh, one needs to happen before the other), and gaining 15 lbs. plus. Lastly, I understand that Liebowitz, et al., of the New York State Psychiatric Institute found the reversible MAO inhibitors (RIMA's), namely Moclobemide, to be no better than placebo in their more recent follow-up studies.
>
> Thanks.
poster:Rick
thread:11298
URL: http://www.dr-bob.org/babble/19990914/msgs/11618.html