Posted by Elizabeth on July 13, 1999, at 21:25:29
In reply to Re: Serzone +Buspar warning confirmed, posted by elizabeth on July 13, 1999, at 15:46:13
Elizabeth-
I didn't understand all of the medical terminology relating to the interaction between Buspar and Nefazodone. Could you possibly explain it in non-medicalese?
> According to the updated PI, Buspar is metabolized into 1-pyrimidinylpiperazine (1-PP) by CYP3A4, an enzyme inhibited by nefazodone. Therefore, buspirone levels will be higher and 1-PP levels lower if Buspar and Serzone are taken together.
> Therefore, they recommend starting at a very low dose of Buspar (i.e., starting at 2.5mg bid) if you're on Serzone as well.
Does this mean that you can take Buspar with Serzone?
Thanks for the clarification, I am really confused about this and don't feel comfortable talking to my doctor (fairly obvious from my last post).
Erin
poster:Elizabeth
thread:6943
URL: http://www.dr-bob.org/babble/19990628/msgs/8680.html