Psycho-Babble Alternative Thread 1113182

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N-Acetyl Cysteine Newer Research, anyone try?

Posted by Mtom on December 31, 2020, at 10:56:45

Im reading papers suggesting that in depression, dysfunction of glutamatergic neurotransmission in the brain my be implicated. There is research suggesting that N-Acetyl Cysteine (NAC) regulates brain glutamate. Most articles say it is safe in low doses however other articles have cautions about using NAC for various reasons. Im still trying to read up on it.

I see only one recent thread on NAC, with limited discussion. Research seems to have grown in recent years if you do a PubMed search for depression, bipolar disorder, schizophrenia, OCD, neuro-degenerative illnesses, etc.

Studies seem to indicate it takes several months of supplementation to see an effect. Heres a link to download the PDF of a recent 2020 Review article (also discusses Vitamin D which I didnt read as I already supplement Vitamin D and have had my levels tested, are good). https://www.researchgate.net/publication/340469174_Vitamin_D_and_N-Acetyl_Cysteine_Supplementation_in_Treatment-Resistant_Depressive_Disorder_Patients_A_General_Review/link/5f69e02f92851c14bc8e098d/download

Has anyone tried NAC recently, or researched it? What dose? Any side-effects or interactions with meds? Also what are the negatives of NAC supplementation (especially long term)?

 

Re: N-Acetyl Cysteine Newer Research, anyone try?

Posted by Lamdage22 on January 12, 2021, at 4:38:42

In reply to N-Acetyl Cysteine Newer Research, anyone try?, posted by Mtom on December 31, 2020, at 10:56:45

If you want to raise Glutathione, you can take S-Acetyl-Glutathione. I am having a blood test tomorrow. If it is low(ish), I will supplement it.

 

Re: N-Acetyl Cysteine Newer Research, anyone try? Mtom

Posted by NKP on January 18, 2021, at 16:08:25

In reply to N-Acetyl Cysteine Newer Research, anyone try?, posted by Mtom on December 31, 2020, at 10:56:45

> Im reading papers suggesting that in depression, dysfunction of glutamatergic neurotransmission in the brain my be implicated. There is research suggesting that N-Acetyl Cysteine (NAC) regulates brain glutamate. Most articles say it is safe in low doses however other articles have cautions about using NAC for various reasons. Im still trying to read up on it.
>
> I see only one recent thread on NAC, with limited discussion. Research seems to have grown in recent years if you do a PubMed search for depression, bipolar disorder, schizophrenia, OCD, neuro-degenerative illnesses, etc.
>
> Studies seem to indicate it takes several months of supplementation to see an effect. Heres a link to download the PDF of a recent 2020 Review article (also discusses Vitamin D which I didnt read as I already supplement Vitamin D and have had my levels tested, are good). https://www.researchgate.net/publication/340469174_Vitamin_D_and_N-Acetyl_Cysteine_Supplementation_in_Treatment-Resistant_Depressive_Disorder_Patients_A_General_Review/link/5f69e02f92851c14bc8e098d/download
>
> Has anyone tried NAC recently, or researched it? What dose? Any side-effects or interactions with meds? Also what are the negatives of NAC supplementation (especially long term)?
>

I presume that you are referring to the following thread of mine:

http://www.dr-bob.org/babble/alter/20190907/msgs/1109502.html

I've experienced near miraculous effects from NAC.

I've also come across the following article however that argues that antioxidant supplementation is not necessarily a good thing:

https://blogs.sciencemag.org/pipeline/archives/2019/10/04/n-acetyl-cysteine-a-warning-shot

There is conflicting evidence that some cancers may be more common in people who supplement with antioxidants.

 

Additional published papers on NAC, Depression,etc NKP

Posted by Mtom on January 19, 2021, at 12:46:55

In reply to Re: N-Acetyl Cysteine Newer Research, anyone try? Mtom, posted by NKP on January 18, 2021, at 16:08:25

Yes NKP I had read that article you linked. One has to be aware not only that there is often a trade-off in treating any condition, but that in many incidences, we don't know what the long-term trade-off might be. This goes for pharmaceutical drugs as well as supplements.

Caveats (and they may be significant) aside, I found another published paper, a 2016 meta-analysis of 5 Placebo controlled Clinical Trials examining N-acetyl Cysteine for depression. They found that NAC had a moderate effect over placebo in decreasing depressive symptoms and improving functionality over 12 to 24 week follow ups.
Link to download the PDF article: https://www.researchgate.net/publication/301816290_N-Acetylcysteine_in_Depressive_Symptoms_and_Functionality_A_Systematic_Review_and_Meta-Analysis/link/59e6ff84aca2721fc2304856/download

Here is another 2018 article "Application of N-Acetylcysteine in Psychiatric Disorders". It includes the abstract, not the full paper, but does have links to a number of tables from the paper summarizing results of studies investigating NAC for a number of psychiatric disorders. https://link.springer.com/chapter/10.1007%2F978-981-10-5311-5_12

> I presume that you are referring to the following thread of mine:
>
> http://www.dr-bob.org/babble/alter/20190907/msgs/1109502.html
>
> I've experienced near miraculous effects from NAC.
>
> I've also come across the following article however that argues that antioxidant supplementation is not necessarily a good thing:
>
> https://blogs.sciencemag.org/pipeline/archives/2019/10/04/n-acetyl-cysteine-a-warning-shot
>
> There is conflicting evidence that some cancers may be more common in people who supplement with antioxidants.


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