Psycho-Babble Medication Thread 1121503

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Lumateperone (Caplyta) for depression?

Posted by SLS on January 7, 2023, at 7:25:32

Has anyone tried lumateperone (Caplyta) to treat depression? This drug was approved by the FDA in 2019 as an antipsychotic to treat schizophrenia. In 2021, the FDA approved lumateperone for both Bipolar I and Bipolar II depression.

Is lumateperone superior to lurasidone for treating depression?

This article describes a clinical trial using lumateperone for treating:

- Bipolar I Depression
- Bipolar II depression

* Major Depressive Disorder (MDD) - Clinical trials are ongoing.

------------------------------------------------------------------

"Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial"


https://pubmed.ncbi.nlm.nih.gov/34551584/


- Scptt

 

Re: Lumateperone (Caplyta) for depression? SLS

Posted by Jay2112 on January 7, 2023, at 21:25:16

In reply to Lumateperone (Caplyta) for depression?, posted by SLS on January 7, 2023, at 7:25:32

What are it's mechanisms?


Jay

 

Re: Lumateperone (Caplyta) for depression? SLS

Posted by TriedEveryMedication on January 12, 2023, at 8:44:01

In reply to Lumateperone (Caplyta) for depression?, posted by SLS on January 7, 2023, at 7:25:32

> Has anyone tried lumateperone (Caplyta) to treat depression? This drug was approved by the FDA in 2019 as an antipsychotic to treat schizophrenia. In 2021, the FDA approved lumateperone for both Bipolar I and Bipolar II depression.
>

I tried it. It made my depression so much worse that I had to bail after 3 days.

 

Re: Lumateperone (Caplyta) for depression? TriedEveryMedication

Posted by SLS on January 12, 2023, at 11:32:41

In reply to Re: Lumateperone (Caplyta) for depression? SLS, posted by TriedEveryMedication on January 12, 2023, at 8:44:01

> > Has anyone tried lumateperone (Caplyta) to treat depression? This drug was approved by the FDA in 2019 as an antipsychotic to treat schizophrenia. In 2021, the FDA approved lumateperone for both Bipolar I and Bipolar II depression.
> >
>
> I tried it. It made my depression so much worse that I had to bail after 3 days.


I'm sorry to hear that. It's always something with these drugs. I had to bail on several drugs within three days of starting them. Moclobemide was by far the worst for me.

What medical conditions are you trying to treat?


- Scott

 

Re: Lumateperone (Caplyta) for depression? SLS

Posted by TriedEveryMedication on January 14, 2023, at 10:12:45

In reply to Re: Lumateperone (Caplyta) for depression? TriedEveryMedication, posted by SLS on January 12, 2023, at 11:32:41

> What medical conditions are you trying to treat?
>
>
> - Scott
>
>

Depression (much worse in the morning for some reason), extreme rumination, GAD

 

Re: Lumateperone (Caplyta) for depression? TriedEveryMedication

Posted by SLS on January 14, 2023, at 17:34:39

In reply to Re: Lumateperone (Caplyta) for depression? SLS, posted by TriedEveryMedication on January 14, 2023, at 10:12:45

> > What medical conditions are you trying to treat?
> >
> >
> > - Scott
> >
> >
>
> Depression (much worse in the morning for some reason), extreme rumination, GAD
>

Your symptoms are consistent with melancholic (endogenous) depression. As such, it would be more likely to respond to a tricyclic than to a SSRI. GAD is something different. Believe it or not, Nardil is probably the most effective drug to treat that. Also, a SSRI should be better than a tricyclic for GAD. Of the SSRIs, Paxil (paroxetine) might be the most effective, but I would not make that my first choice. It is also the SSRI most likely to produce weight gain and sexual dysfunction. Additionally, it is the hardest SSRI to discontinue due to a withdrawal syndrome.

Regarding tricyclics, I favor nortriptyline because it is the most tolerable with respect to side effects. For me, it is a much better "mood brightener" than the other tricyclics. Of course, you might not respond to it. Clomipramine has anti-obsessional properties that are probably stronger than that of any other available drug. This might be a result of the combination of norepinephrine reuptake inhibibtion and serotonin reuptake inhibibion. Clomipramine acts liked of hybrid between a TCA and a SSRI. Unfortunately, it is a really "dirty" drug. The side effects also seem to be hybrids of these two types of drugs. Anticholinergic side effects are pretty strong and yield a great many side effects.

You might not need an anti-obsessional. Melancholic depression often presents with rumination.

https://pubmed.ncbi.nlm.nih.gov/3160746/


- Scott


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