Psycho-Babble Medication Thread 1121495

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Guanfacine + NAC for PTSD, TBI, ADHD, long Covid

Posted by Hugh on January 6, 2023, at 8:34:11

Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.

Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.

Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.

https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub

https://www.yalemedicine.org/news/long-covid-brain-fog-treatment

 

Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid Hugh

Posted by SLS on January 6, 2023, at 12:53:52

In reply to Guanfacine + NAC for PTSD, TBI, ADHD, long Covid, posted by Hugh on January 6, 2023, at 8:34:11

> Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.
>
> Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.
>
> Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.
>
> https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub
>
> https://www.yalemedicine.org/news/long-covid-brain-fog-treatment


Does guanfacine produce depression as a side effect as often as clonidine does?


- Scott

 

Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid SLS

Posted by Jay2112 on January 6, 2023, at 19:58:49

In reply to Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid Hugh, posted by SLS on January 6, 2023, at 12:53:52

> > Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.
> >
> > Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.
> >
> > Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.
> >
> > https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub
> >
> > https://www.yalemedicine.org/news/long-covid-brain-fog-treatment
>
>
> Does guanfacine produce depression as a side effect as often as clonidine does?
>
>
> - Scott

I don't think guanfacine is as strong a sedative as clonidine. I honestly did not find clonidine depressing, but just that it slows you down. I think because of the norepinephrine suppression, it also makes you achy and tired. But that is dose dependent.

Jay


 

Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid

Posted by SLS on January 6, 2023, at 20:14:30

In reply to Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid SLS, posted by Jay2112 on January 6, 2023, at 19:58:49

> > > Twelve patients with "brain fog" including difficulties in executive functions were treated with guanfacine (1mg, PO [by mouth] bedtime for the first month, increased to 2mg after 1 month, if well-tolerated) and 600 mg NAC daily.
> > >
> > > Guanfacine+NAC improved cognitive abilities in eight of the twelve patients; four patients discontinued therapy, two for unspecified reasons and two due to hypotension and/or dizziness, common side effects of guanfacine.
> > >
> > > Those who stayed on guanfacine+NAC reported improved working memory, concentration, and executive functions, including a resumption of normal workloads. One patient briefly stopped taking guanfacine due to a hypotensive episode and reported a return of cognitive deficits that abated with resumed guanfacine treatment.
> > >
> > > https://www.sciencedirect.com/science/article/pii/S2667257X22001000?via%3Dihub
> > >
> > > https://www.yalemedicine.org/news/long-covid-brain-fog-treatment
> >
> >
> > Does guanfacine produce depression as a side effect as often as clonidine does?
> >
> >
> > - Scott
>
> I don't think guanfacine is as strong a sedative as clonidine.


Which is better for ADHD?


> I honestly did not find clonidine depressing, but just that it slows you down. I think because of the norepinephrine suppression, it also makes you achy and tired. But that is dose dependent.

Clonidine is notorious for producing a very real depressive state. A doctor gave my maternal grandmother clonidine for hypertension. She had no history of having a depressive mood disorder. Within a week of beginning clonidine, she became visibly depressed. She laid on the couch and watched Judge Judy all day long. She didn't pick up a book. Reading was her greatest joy. Fortunately, I was well aware of depression being a sequala of taking clonidine. Once she discontinued clonidine, her depression lifted within a few days.


- Scott

 

Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid SLS

Posted by undopaminergic on January 7, 2023, at 9:04:05

In reply to Re: Guanfacine + NAC for PTSD, TBI, ADHD, long Covid, posted by SLS on January 6, 2023, at 20:14:30

> >
> > I don't think guanfacine is as strong a sedative as clonidine.
>
>
> Which is better for ADHD?
>

Guanfacine without question. The evidence was strong enough that Shire was able to get their special form of guanfacine, Intuniv, FDA-approved for the treatment of ADHD.

-undopaminergic


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