Psycho-Babble Medication Thread 1121431

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Vortioxetine plus caffeine

Posted by undopaminergic on December 31, 2022, at 13:55:06

I'm on vortioxetine 5 mg/day and have been on it for about 3 weeks.

I had the opportunity to perform a little experiment.

Caffeine alone normally does nothing for me, even at high doses. Once, I took 3000 mg and got no stimulant effect. All it did was give me the worst night in my whole life, as I got extremely sick to my stomach.

Caffeine does work very well for me with a proper dopaminergic stimulant like methyl- or ethylphenidate in the background. It adds a major nootropic dimension to the dopaminergic drug. I get an almost "flight" of ideas, a cavalcade of interesting ideas. Furthermore, it has general, "normal" stimulant effects like enhancement of wakefulness.

So, I was going to see how caffeine worked with vortioxetine in the background. So, I took 500 mg, and I was pleasantly surprised! I wasn't expecting any effect at all, but I felt less apathetic, more awake, more attentive, and more energetic. I read some neuroscientific (full) articles and was comprehending them well.

Alas, I was unable to reproduce the experience the day after with the same 500 mg amount. It may be that a higher dose would have worked, but I didn't want to get into a chase for a high that takes higher and higher doses.

Has anyone else found that caffeine only works in combination with other drugs? Which ones?

-undopaminergic

 

Re: Vortioxetine plus caffeine undopaminergic

Posted by beckett2 on January 1, 2023, at 18:43:27

In reply to Vortioxetine plus caffeine, posted by undopaminergic on December 31, 2022, at 13:55:06

Trintellix (20 mg) doesn't potentiate my caffeine in any way. I could drink a cup of coffee before bed.

 

Re: Vortioxetine plus caffeine undopaminergic

Posted by beckett2 on January 1, 2023, at 18:45:25

In reply to Vortioxetine plus caffeine, posted by undopaminergic on December 31, 2022, at 13:55:06

3,000 mg! I bet you had a bad night :(

Do you watch Chubby Emu's YouTube channel? Not that you approached the levels of this guy

https://youtu.be/sylqJ0NEVJw

 

Re: Vortioxetine plus caffeine beckett2

Posted by undopaminergic on January 3, 2023, at 9:49:31

In reply to Re: Vortioxetine plus caffeine undopaminergic, posted by beckett2 on January 1, 2023, at 18:45:25

> 3,000 mg! I bet you had a bad night :(
>

Yeah. I was desperate to get up and out of the apathy. Caffeine was the only stimulant I had.

> Do you watch Chubby Emu's YouTube channel?

No.

> Not that you approached the levels of this guy
>
> https://youtu.be/sylqJ0NEVJw
>

Interesting!

-undopaminergic


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