Psycho-Babble Medication Thread 1120868

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Re: Urinary retention. Anticholinergic side effect?

Posted by linkadge on October 22, 2022, at 15:11:09

In reply to Urinary retention. Anticholinergic side effect?, posted by Lamdage22 on October 22, 2022, at 12:19:17

There is Bethanechol (a peripherally acting cholinergic agonist).

Linkadge

 

Re: Neuroleptics decrease bladder voiding? Lamdage22

Posted by jay2112 on October 22, 2022, at 15:19:14

In reply to Neuroleptics decrease bladder voiding?, posted by Lamdage22 on October 22, 2022, at 11:37:13

With Zyprexa, I had absolute opposite. I would wake up each morning with a wet bed. Plus, I would be driving on the highway then just pee'd my pants...zilch control.

Jay

 

Re: Urinary retention. Anticholinergic side effect?

Posted by NKP on October 23, 2022, at 8:44:06

In reply to Urinary retention. Anticholinergic side effect?, posted by Lamdage22 on October 22, 2022, at 12:19:17

> Is it an anticholinergic side effect? What could be an antidote to this?

Yes, urinary retention is an anticholinergic effect. In fact, overactive bladder is treated with anti-cholinergics.

I have the opposite problem. Ever since I started venlafaxine, I need to urinate very frequently, including at night, which is inconvenient.

 

Re: Neuroleptics decrease bladder voiding?

Posted by undopaminergic on October 23, 2022, at 9:47:35

In reply to Neuroleptics decrease bladder voiding?, posted by Lamdage22 on October 22, 2022, at 11:37:13

>
> Now the urologist wants me to take saw palmetto to help. But it does curb DHT, a potent androgen. Are there alternatives? I am worried about my virility.
>

Dihydrotestosterone (DHT) is considerably more potent than testosterone, so you might think it is better than the latter, but that is not true for muscle tissue; citing from Wikipedia:
<<In addition, unlike testosterone, DHT is inactivated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) into the very weak androgen 3alpha-androstanediol in various tissues such as muscle, adipose, and liver among others, and in relation to this, DHT has been reported to be a very poor anabolic agent when administered exogenously as a medication.>>
Reference: https://en.wikipedia.org/wiki/Dihydrotestosterone

I'm not up to date about the pharmacology of saw palmetto, but finasteride and dutasteride, by inhibiting DHT synthesis, increase testosterone (but also estradiol; maybe you could add anastrazole or a similar drug to prevent that).

-undopaminergic

 

Re: Urinary retention. Anticholinergic side effect?

Posted by undopaminergic on October 23, 2022, at 9:51:01

In reply to Urinary retention. Anticholinergic side effect?, posted by Lamdage22 on October 22, 2022, at 12:19:17

> Is it an anticholinergic side effect? What could be an antidote to this?

Yes, it is an anticholinergic effect, but I don't think Zyprexa and Seroquel are particularly potent anticholinergics.

-undopaminergic

 

Re: Urinary retention. Anticholinergic side effect?

Posted by Lamdage22 on October 24, 2022, at 11:49:48

In reply to Re: Urinary retention. Anticholinergic side effect?, posted by undopaminergic on October 23, 2022, at 9:51:01

Thanks guys. Well the bladder doesnt empty, more than 100ml remain and according to my Urologist, this fact leads to having to pee more often. I have to pee too often, just saying to make sure I get the right advice. I also seem to have bladder inflammation as a result of the the urine that remains in the bladder.

The prostate is as large as one would expect for mid 30.

Thoughts?

 

Help?

Posted by Lamdage22 on October 26, 2022, at 7:43:07

In reply to Re: Urinary retention. Anticholinergic side effect?, posted by Lamdage22 on October 24, 2022, at 11:49:48

> Thanks guys. Well the bladder doesnt empty, more than 100ml remain and according to my Urologist, this fact leads to having to pee more often. I have to pee too often, just saying to make sure I get the right advice. I also seem to have bladder inflammation as a result of the the urine that remains in the bladder.
>
> The prostate is as large as one would expect for mid 30.
>
> Thoughts?

Psychiatrist doesnt have any ideas. Id hate to curb down my DHT, as it was not anywhere near a high level in 2020.

 

Re: Help?

Posted by undopaminergic on October 26, 2022, at 12:31:06

In reply to Help?, posted by Lamdage22 on October 26, 2022, at 7:43:07

>
> Psychiatrist doesnt have any ideas. Id hate to curb down my DHT, as it was not anywhere near a high level in 2020.
>

Why do you want DHT? It's a poor anabolic agent, and is associated with male pattern baldness, enlarged prostate, acne, and probably more. I'd pay to get rid of it.

-undopaminergic

 

Re: Help?

Posted by Lamdage22 on October 27, 2022, at 5:58:39

In reply to Re: Help?, posted by undopaminergic on October 26, 2022, at 12:31:06

> >
> > Psychiatrist doesnt have any ideas. Id hate to curb down my DHT, as it was not anywhere near a high level in 2020.
> >
>
> Why do you want DHT? It's a poor anabolic agent, and is associated with male pattern baldness, enlarged prostate, acne, and probably more. I'd pay to get rid of it.
>
> -undopaminergic

Its a preoccupation that androgens are good and estrogens are bad, I guess. I am scared to be less of a man due to the blockade of DHT. But I also take Metformin which evidently lowers testosterone. I don't care much about male pattern hair loss, although I do have some.

 

Re: Help?

Posted by undopaminergic on October 27, 2022, at 6:22:22

In reply to Re: Help?, posted by Lamdage22 on October 27, 2022, at 5:58:39

> > >
> > > Psychiatrist doesnt have any ideas. Id hate to curb down my DHT, as it was not anywhere near a high level in 2020.
> > >
> >
> > Why do you want DHT? It's a poor anabolic agent, and is associated with male pattern baldness, enlarged prostate, acne, and probably more. I'd pay to get rid of it.
> >
> > -undopaminergic
>
> Its a preoccupation that androgens are good and estrogens are bad, I guess. I am scared to be less of a man due to the blockade of DHT. But I also take Metformin which evidently lowers testosterone. I don't care much about male pattern hair loss, although I do have some.
>

Apparently you have a strong gender identity, although you don't seem to feel very secure about it. I'm personally neutral, but have been female for periods.

-undopaminergic

 

Re: Help?

Posted by Lamdage22 on October 27, 2022, at 10:47:20

In reply to Re: Help?, posted by undopaminergic on October 27, 2022, at 6:22:22

> > > >
> > > > Psychiatrist doesnt have any ideas. Id hate to curb down my DHT, as it was not anywhere near a high level in 2020.
> > > >
> > >
> > > Why do you want DHT? It's a poor anabolic agent, and is associated with male pattern baldness, enlarged prostate, acne, and probably more. I'd pay to get rid of it.
> > >
> > > -undopaminergic
> >
> > Its a preoccupation that androgens are good and estrogens are bad, I guess. I am scared to be less of a man due to the blockade of DHT. But I also take Metformin which evidently lowers testosterone. I don't care much about male pattern hair loss, although I do have some.
> >
>
> Apparently you have a strong gender identity, although you don't seem to feel very secure about it. I'm personally neutral, but have been female for periods.
>
> -undopaminergic

We are talking about physical maleness though. Not about personality traits.

 

Re: Help?

Posted by Lamdage22 on October 27, 2022, at 10:54:47

In reply to Re: Help?, posted by Lamdage22 on October 27, 2022, at 10:47:20

A mans hormone levels should be kept in other ranges than a womans, right?

 

Re: Help?

Posted by undopaminergic on October 27, 2022, at 13:03:18

In reply to Re: Help?, posted by Lamdage22 on October 27, 2022, at 10:54:47

> A mans hormone levels should be kept in other ranges than a womans, right?

In the general case, I'm sure.

-undopaminergic

 

Alpha blockers?

Posted by Lamdage22 on October 27, 2022, at 14:31:12

In reply to Re: Help?, posted by undopaminergic on October 27, 2022, at 13:03:18

They leave androgens alone and they can help bladder voiding.

 

Re: Alpha blockers?

Posted by undopaminergic on October 28, 2022, at 7:46:19

In reply to Alpha blockers?, posted by Lamdage22 on October 27, 2022, at 14:31:12

> They leave androgens alone and they can help bladder voiding.

So try it then?

Have you tried squeezing the bladder as you pee? I usually do that, and it often helps.

-undopaminergic

 

Re: Alpha blockers?

Posted by Lamdage22 on October 29, 2022, at 3:12:51

In reply to Re: Alpha blockers?, posted by undopaminergic on October 28, 2022, at 7:46:19

> > They leave androgens alone and they can help bladder voiding.
>
> So try it then?
>
> Have you tried squeezing the bladder as you pee? I usually do that, and it often helps.
>
> -undopaminergic

I will try to try. Got another urologist appointment in a few weeks. My general practitioner is on my side. She says the prostate is not even enlarged and my dht levels are in the lower half of the reference range.

Doesn't make sense if there are other options.

Your voice can get higher with this dht blocking sh*t. And beard growth can lessen. Women put saw palmetto cream on their faces to lessen beard growth and I am supposed to swallow this sh*t.

 

Re: Alpha blockers?

Posted by Lamdage22 on October 29, 2022, at 3:15:36

In reply to Re: Alpha blockers?, posted by Lamdage22 on October 29, 2022, at 3:12:51

> > Have you tried squeezing the bladder as you pee? I usually do that, and it often helps.
> >
> > -undopaminergic

Not yet. How do I do that?

 

Re: Alpha blockers?

Posted by undopaminergic on October 29, 2022, at 10:43:59

In reply to Re: Alpha blockers?, posted by Lamdage22 on October 29, 2022, at 3:15:36

> > > Have you tried squeezing the bladder as you pee? I usually do that, and it often helps.
> > >
> > > -undopaminergic
>
> Not yet. How do I do that?

Push your belly inward with your fingers above the pubic bone.

-undopaminergic

 

Re: Alpha blockers?

Posted by undopaminergic on October 29, 2022, at 10:50:34

In reply to Re: Alpha blockers?, posted by Lamdage22 on October 29, 2022, at 3:12:51

>
> Your voice can get higher with this dht blocking sh*t. And beard growth can lessen.
>

I doubt it. Ask transsexuals who take estrogens.

I would personally welcome both effects. I've been thinking of buying laser hair removal/reduction equipment, but I'm concerned it might not work on gray/white hair.

-undopaminergic

 

Re: Alpha blockers?

Posted by Lamdage22 on October 30, 2022, at 2:42:19

In reply to Re: Alpha blockers?, posted by undopaminergic on October 29, 2022, at 10:50:34

> I would personally welcome both effects. I've been thinking of buying laser hair removal/reduction equipment, but I'm concerned it might not work on gray/white hair.
>
> -undopaminergic

Why?

 

Re: Alpha blockers?

Posted by undopaminergic on October 30, 2022, at 10:15:01

In reply to Re: Alpha blockers?, posted by Lamdage22 on October 30, 2022, at 2:42:19

> > I would personally welcome both effects. I've been thinking of buying laser hair removal/reduction equipment, but I'm concerned it might not work on gray/white hair.
> >
> > -undopaminergic
>
> Why?
>

Why what? Hair removal? So that I don't have to shave.

-undopaminergic

 

Re: Alpha blockers?

Posted by ed_uk on December 4, 2022, at 13:36:10

In reply to Alpha blockers?, posted by Lamdage22 on October 27, 2022, at 14:31:12

Seroquel is an alpha blocker already.

Additional alpha blockers such as tamsulosin on top of the meds you already take could easily cause sexual side effects such as inhibiting ejaculation.

I'd suggest you speak to your doc about the doses of antipsychotics you're taking. If I recall, they were very high, which is probably the reason for the side effects.

Drugs like finasteride (Proscar) are normally used for men over 50 with prostate enlargement. Finasteride reduces DHT and prevents further prostate enlargement. I think you're much younger, but I could be wrong.

 

Re: Alpha blockers?

Posted by Lamdage22 on December 8, 2022, at 9:16:29

In reply to Re: Alpha blockers?, posted by ed_uk on December 4, 2022, at 13:36:10

> I'd suggest you speak to your doc about the doses of antipsychotics you're taking. If I recall, they were very high, which is probably the reason for the side effects.

You are right, see my signature. I told my doctor about the problem, he said I can't withdraw the Neuroleptics. Reducing them would probably come with sleeplessness, that is why I dpm't ask for a reduced dose. But I can't maintain regular sleep without occasional as needed GABAergic drugs. 1 out of 3 nights, I need some Lorazepam. So yeah, maybe I should just sleep less and thus be more naturally tired? I am sort of "enforcing" falling asleep by taking stuff. Maybe I shouldn't. What do you think? It seems I need more as years go on. And I still have a long way to go.

 

Re: Alpha blockers? Lamdage22

Posted by SLS on December 8, 2022, at 13:11:41

In reply to Re: Alpha blockers?, posted by Lamdage22 on December 8, 2022, at 9:16:29

Hi, Linkadge.

How does the metformin function in your regime?


- Scott

 

Re: Alpha blockers?

Posted by Lamdage22 on December 9, 2022, at 2:47:00

In reply to Re: Alpha blockers? Lamdage22, posted by SLS on December 8, 2022, at 13:11:41

> Hi, Linkadge.
>
> How does the metformin function in your regime?
>
>
> - Scott

Its Lamdage here. The thought behind Metformin was that it can help metabolic syndrome. Its a problem I have with the Neuroleptics. I can't tell if it helps mood or not.


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