Psycho-Babble Medication Thread 1117052

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'Pacemaker' ion channels

Posted by undopaminergic on September 23, 2021, at 12:29:09

Hi all,

I just came across this:

Hyperpolarisation-activated Cyclic Nucleotide-gated ion channels help maintain the "rhythm" of groups of cells in the CNS and heart. Among others, it seems they play a role in the 4 Hz tonic firing pattern of VTA (Ventral Tegmental Area) dopamine neurons.



Re: 'Pacemaker' ion channels

Posted by linkadge on September 23, 2021, at 15:00:38

In reply to 'Pacemaker' ion channels, posted by undopaminergic on September 23, 2021, at 12:29:09

Interesting. I think some of the TCAs might bind to HCN channels (if I recall).


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