Psycho-Babble Medication Thread 1115683

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

Licorice

Posted by linkadge on June 30, 2021, at 13:22:30

I'm trying some licorice based on its purported effects on MAOB. I have benefitted from other herbs that purportedly inhibit MAOB so I'm seeing if there is any common benefit:

https://www.researchgate.net/figure/Most-potent-herbal-extract-inhibitors-of-human-MAO-B-activity-The-data-represent-product_fig2_230658885

Linkadge

 

Re: Licorice

Posted by rjlockhart37 on June 30, 2021, at 21:39:36

In reply to Licorice, posted by linkadge on June 30, 2021, at 13:22:30

i'm the least researchive, but licourice has many health benefits - antioxidant, respirtory system, it's been used in herbal medicine for quite a while but has negative effects on health when taken too much intake

https://www.businessinsider.com/science-healthy-licorice-2017-3

but still i was never a fan licorice candy, taste too black flavor, yuk

 

Re: Licorice

Posted by undopaminergic on July 1, 2021, at 11:06:24

In reply to Licorice, posted by linkadge on June 30, 2021, at 13:22:30

> I'm trying some licorice based on its purported effects on MAOB. I have benefitted from other herbs that purportedly inhibit MAOB so I'm seeing if there is any common benefit:
>
> https://www.researchgate.net/figure/Most-potent-herbal-extract-inhibitors-of-human-MAO-B-activity-The-data-represent-product_fig2_230658885
>

So are these stronger than Harmala?

Have you ever tried selegiline or rasagiline?

You also said you were using PEA. Have you tried it in combination with MAO-B inhibitors? Be careful; my first dose of PEA with selegiline raised my blood pressure to the point where the baroreceptors kicked in and lowered my heart rate to 60 or below (from my normal 80+ bpm resting pulse; I did not have a blood pressure monitor when this happened).

-undopaminergic

 

Re: Licorice

Posted by linkadge on July 1, 2021, at 13:32:47

In reply to Re: Licorice, posted by undopaminergic on July 1, 2021, at 11:06:24

No I've never tried selegiline, but I would like to at some point. The problem is that (here in Canada) its not approved for depression (aka Emsam in the US). Also, I'm not really comfortable going to online (no script) pharmacies.

So, there's really no way to try it out. While there are some studies using Selegeline + PEA for depression, the data is too scant for most doctors to look at this seriously.

Linkadge

 

interactions with SSRIs? linkadge

Posted by TriedEveryMedication on July 18, 2021, at 17:16:41

In reply to Licorice, posted by linkadge on June 30, 2021, at 13:22:30

> I'm trying some licorice based on its purported effects on MAOB. I have benefitted from other herbs that purportedly inhibit MAOB so I'm seeing if there is any common benefit:
>
> https://www.researchgate.net/figure/Most-potent-herbal-extract-inhibitors-of-human-MAO-B-activity-The-data-represent-product_fig2_230658885
>
> Linkadge
>
>


I'm interested in this and I wonder if it has the same risks as pharma maoi-b's with ssris.

I googled around, there doesn't seem to be much out there.

 

Re: interactions with SSRIs?

Posted by undopaminergic on July 19, 2021, at 7:41:28

In reply to interactions with SSRIs? linkadge, posted by TriedEveryMedication on July 18, 2021, at 17:16:41

> > I'm trying some licorice based on its purported effects on MAOB. I have benefitted from other herbs that purportedly inhibit MAOB so I'm seeing if there is any common benefit:
> >
> > https://www.researchgate.net/figure/Most-potent-herbal-extract-inhibitors-of-human-MAO-B-activity-The-data-represent-product_fig2_230658885
> >
> > Linkadge
> >
> >
>
>
> I'm interested in this and I wonder if it has the same risks as pharma maoi-b's with ssris.
>
> I googled around, there doesn't seem to be much out there.

MAO-B does not break down serotonin, so as long as the drug is selective for MAO-B, it can be combined with SSRIs without risk. With partially selective agents it would depend on the dose.

-undopaminergic


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