Psycho-Babble Medication Thread 1114241

Shown: posts 1 to 9 of 9. This is the beginning of the thread.

 

Some psych meds are COVID-19 Protective:

Posted by PeterMartin on March 23, 2021, at 16:35:45

New study (March 23, 2001):

Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants in vitro

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Background and Purpose: Repurposing of currently available drugs is a valuable strategy to tackle the consequences of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on SARS-CoV-2 in cell culture models as well as in clinical practice. Our aim was to expand these studies and test some of these compounds against newly emerged variants.

Experimental Approach: Several antidepressant drugs and antipsychotic drugs with different primary mechanisms of action were tested in ACE2/TMPRSS2-expressing human embryonic kidney cells against the infection by SARS-CoV-2 spike protein-dependent pseudoviruses. Some of these compounds were also tested in human lung epithelial cell line, Calu-1, against the first wave (B.1) lineage of SARS-CoV-2 and the variants of concern, B.1.1.7 and B.1.351. Key

Results: Several clinically used antidepressants, including fluoxetine, citalopram, reboxetine, imipramine, as well as antipsychotic compounds chlorpromazine, flupenthixol, and pimozide inhibited the infection by pseudotyped viruses with minimal effects on cell viability.

The antiviral action of several of these drugs was verified in Calu-1 cells against the (B.1) lineage of SARS-CoV-2.


By contrast, the anticonvulsant carbamazepine, and novel antidepressants ketamine and its derivatives as well as MAO and phosphodiesterase inhibitors phenelzine and rolipram, respectively, showed no activity in the pseudovirus model.

Furthermore, fluoxetine remained effective against pseudo viruses with N501Y, K417N, and E484K spike mutations, and the VoC-1 (B.1.1.7) and VoC-2 (B.1.351) variants of SARS-CoV-2. Conclusion and Implications: Our study confirms previous data and extends information on the repurposing of these drugs to counteract SARS-CoV-2 infection including different variants of concern.
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https://www.biorxiv.org/content/10.1101/2021.03.22.436379v1

 

Re: Some psych meds are COVID-19 Protective: PeterMartin

Posted by Phillipa on March 24, 2021, at 9:08:14

In reply to Some psych meds are COVID-19 Protective:, posted by PeterMartin on March 23, 2021, at 16:35:45

I see Luvox, fluvoxitine isn't included. But studies show that it does work? Thanks Phillipa

 

Re: Some psych meds are COVID-19 Protective:

Posted by rjlockhart37 on March 25, 2021, at 18:44:14

In reply to Re: Some psych meds are COVID-19 Protective: PeterMartin, posted by Phillipa on March 24, 2021, at 9:08:14

i wish prozac was on that list

 

Re: Some psych meds are COVID-19 Protective:

Posted by rjlockhart37 on March 25, 2021, at 18:45:53

In reply to Some psych meds are COVID-19 Protective:, posted by PeterMartin on March 23, 2021, at 16:35:45

oh wait you are right, fluoxetine is included, hope my figers i can just take prozac and not get the vaccine

 

Re: Some psych meds are COVID-19 Protective:

Posted by Christ_empowered on March 25, 2021, at 23:43:22

In reply to Re: Some psych meds are COVID-19 Protective:, posted by rjlockhart37 on March 25, 2021, at 18:45:53

why only older neuroleptics on the list? weird...


but I'm glad the psych drugs can find additional uses. :-)

 

Re: Some psych meds are COVID-19 Protective:

Posted by PeterMartin on March 25, 2021, at 23:51:24

In reply to Re: Some psych meds are COVID-19 Protective: PeterMartin, posted by Phillipa on March 24, 2021, at 9:08:14

> I see Luvox, fluvoxitine isn't included. But studies show that it does work? Thanks Phillipa

Yea, this study just focused on certain medications. From others I've see Luvox is the front runner for having potential to help w/ COVID infection. This is because it acts on the sigma-1 receptor unlike most other SSRIs/etc.

I think they're doing trials w/ Luvox to see how it might affect the course of illness. The medications in this study are speculative.

 

Re: Some psych meds are COVID-19 Protective: PeterMartin

Posted by Phillipa on March 26, 2021, at 10:38:25

In reply to Re: Some psych meds are COVID-19 Protective:, posted by PeterMartin on March 25, 2021, at 23:51:24

I read trials also. What is the sigma receptor? Thanks Phillipa

 

Re: Some psych meds are COVID-19 Protective:

Posted by rjlockhart37 on April 10, 2021, at 20:15:49

In reply to Re: Some psych meds are COVID-19 Protective:, posted by rjlockhart37 on March 25, 2021, at 18:45:53

i got the vaccine, pfizer. It's suppost to be good vacinne. Being around covid, at first i hated the thought on getting it. My 2nd dose is in 3 weeks

 

Re: Some psych meds are COVID-19 Protective: rjlockhart37

Posted by Phillipa on April 10, 2021, at 20:50:42

In reply to Re: Some psych meds are COVID-19 Protective:, posted by rjlockhart37 on April 10, 2021, at 20:15:49

That is the best one now I feel. When got the J&J thought it was but since Pfizer is waiting for EAU for kids now ages 7-12 since 100% effective in the trials. I do feel this is the best vaccine. Phillipa


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