Psycho-Babble Medication Thread 1113974

Shown: posts 1 to 13 of 13. This is the beginning of the thread.

 

Bipolar brain inflammation

Posted by linkadge on March 4, 2021, at 15:42:20

Hi all,

I read an interesting article on the link between bipolar and brain inflammation.

https://www.msn.com/en-ca/health/medical/scientists-find-link-between-bipolar-disorder-and-neuroinflammation/ar-BB1eeSBH?ocid=msedgdhp

I have come to believe that inflammation is a key component in my mood disorder. I have a family history of bipolar (not formally diagnosed myself with bipolar).

I have found the herb feverfew (and DHA) to be somewhat helpful in acute relapses.

Linkadge


 

Re: Bipolar brain inflammation

Posted by Lamdage22 on March 5, 2021, at 1:43:38

In reply to Bipolar brain inflammation, posted by linkadge on March 4, 2021, at 15:42:20

Anti Inflammatory and antioxidant nutrients have had a positive impact on my symptoms. Does oxidative stress equal inflammation? That is my impression

 

Re: Bipolar brain inflammation

Posted by undopaminergic on March 5, 2021, at 8:38:51

In reply to Re: Bipolar brain inflammation, posted by Lamdage22 on March 5, 2021, at 1:43:38

> Anti Inflammatory and antioxidant nutrients have had a positive impact on my symptoms. Does oxidative stress equal inflammation?
>

No, they are different things, but maybe they often occur simultaneously.

I haven't taken much interest in inflammation myself, or I might have been able to give you a better answer.

-undopaminergic

 

Re: Bipolar brain inflammation

Posted by linkadge on March 5, 2021, at 16:35:00

In reply to Re: Bipolar brain inflammation, posted by Lamdage22 on March 5, 2021, at 1:43:38

>Does oxidative stress equal inflammation? That >is my impression.

I think they are separate processes but tend to trigger one another.

Linkadge

 

Re: Bipolar brain inflammation undopaminergic

Posted by linkadge on March 6, 2021, at 9:26:34

In reply to Re: Bipolar brain inflammation, posted by undopaminergic on March 5, 2021, at 8:38:51

>I haven't taken much interest in inflammation >myself, or I might have been able to give you a >better answer.

Of note - inflammation in the brain blocks dopamine synthesis.

Linkadge

 

Re: Bipolar brain inflammation

Posted by undopaminergic on March 6, 2021, at 9:58:54

In reply to Re: Bipolar brain inflammation undopaminergic, posted by linkadge on March 6, 2021, at 9:26:34

> >I haven't taken much interest in inflammation >myself, or I might have been able to give you a >better answer.
>
> Of note - inflammation in the brain blocks dopamine synthesis.
>
> Linkadge

OK, that's pretty bad.

I was wondering whether eg. ibuprofen does anything about this inflammation?

-undopaminergic

 

Re: Bipolar brain inflammation

Posted by linkadge on March 6, 2021, at 12:21:29

In reply to Re: Bipolar brain inflammation, posted by undopaminergic on March 6, 2021, at 9:58:54

Possibly. Some studies suggest that aspirin augments the therapeutic effects of lithium. Celebrex was shown in one study to augment antidepressants. Also TCAs seem to be better at reducing inflammation than SSRIs.

Linkadge

 

Re: Bipolar brain inflammation

Posted by Lamdage22 on March 6, 2021, at 12:30:38

In reply to Re: Bipolar brain inflammation, posted by linkadge on March 6, 2021, at 12:21:29

I have a feeling about aspirin giving me some relief with not just the headache. There certainly is more to Depression than monoamines, but it hasn't translated into meds. Yet.

 

Re: Bipolar brain inflammation

Posted by rjlockhart37 on March 7, 2021, at 16:41:40

In reply to Re: Bipolar brain inflammation, posted by Lamdage22 on March 6, 2021, at 12:30:38

yeah asprin sounds like a good idea, but it also is an acid. taking too much causes stomach problems and bleeding internal. But it's a blood thinner, maybe some how antiinflammatory effects could be benefical, by thinning the blood. Im not educated on this. But that's just an idea. Asprin has no documented effects on treating inflamation for bipolar, manic depression

 

Re: Bipolar brain inflammation

Posted by linkadge on March 9, 2021, at 8:33:47

In reply to Re: Bipolar brain inflammation, posted by rjlockhart37 on March 7, 2021, at 16:41:40

>Asprin has no documented effects on treating >inflamation for bipolar, manic depression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818404/

file:///C:/Users/Tom/AppData/Local/Temp/MicrosoftEdgeDownloads/9b690929-53f6-4f2f-b9e0-5a7bc5fd90c0/brainsci-09-00296.pdf

Linkadge

 

Re: Bipolar brain inflammation

Posted by rjlockhart37 on March 9, 2021, at 14:07:27

In reply to Re: Bipolar brain inflammation, posted by linkadge on March 9, 2021, at 8:33:47

oh wow, didnt know that, i thought asprin would be a good choice first but i didnt know it had docuemted sites that it does, that was the first reaction i had, that asprin could help inflamation and is a blood thinner, guess there is evidence on it

 

Re: Bipolar brain inflammation

Posted by rjlockhart37 on March 9, 2021, at 14:11:37

In reply to Re: Bipolar brain inflammation, posted by rjlockhart37 on March 9, 2021, at 14:07:27

i have extra stength asprin in medicine cabneit, they make 'buffered asprin' to keep it from disturbing stomach, or causing bleeding. Salicylic acid tends to be harsh if used regularly, but like low dose 81mg tiny dose is best

 

Re: Bipolar brain inflammation

Posted by linkadge on March 9, 2021, at 15:19:46

In reply to Re: Bipolar brain inflammation, posted by rjlockhart37 on March 9, 2021, at 14:11:37

Generally, low dose (81mg) is pretty safe, but you should 'check with your doctor' for long term use. That being said, there are other anti-inflammatories (like omega 3) which may achieve the same thing more safely.

Linkadge


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