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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by baseball55 on May 28, 2015, at 20:49:27
http://psychcentral.com/news/2015/05/28/analysis-shows-that-antidepressants-are-effective/85050.html
Posted by Christ_empowered on May 28, 2015, at 20:57:30
In reply to SSRI effectiveness, posted by baseball55 on May 28, 2015, at 20:49:27
I hope they're right. I've been spending too much time at the Mad In America website, so...yeah, lol.
Thanks for this.
Posted by SLS on May 28, 2015, at 22:32:27
In reply to SSRI effectiveness, posted by baseball55 on May 28, 2015, at 20:49:27
> http://psychcentral.com/news/2015/05/28/analysis-shows-that-antidepressants-are-effective/85050.html
Thank you for posting this.
I've been making this argument for years.
Antidepressants work, although seemingly not for most people who come to this website desperately looking for help.
1. Poop out of certain drugs for some people: Yes
2. Worsening of depression by certain drugs for some people: Yes
3. Intolerable side effects of certain drugs for some people: YesThis is the nature of the beast.
- Scott
Posted by Phillipa on May 29, 2015, at 9:42:11
In reply to SSRI effectiveness, posted by baseball55 on May 28, 2015, at 20:49:27
So they do work? Not a placebo effect with what's happening in a persons life being can lift depression? Phillipa
Posted by SLS on May 29, 2015, at 14:31:06
In reply to Re: SSRI effectiveness, posted by Phillipa on May 29, 2015, at 9:42:11
> So they do work? Not a placebo effect with what's happening in a persons life being can lift depression? Phillipa
How do you define or describe depression?
Before one can evaluate the effectiveness of a treatment for depression, one must first identify and describe what depression is.
- Scott
Posted by Phillipa on May 29, 2015, at 18:38:06
In reply to Re: SSRI effectiveness » Phillipa, posted by SLS on May 29, 2015, at 14:31:06
True.
Posted by baseball55 on May 29, 2015, at 20:11:16
In reply to Re: SSRI effectiveness - Finally ! » baseball55, posted by SLS on May 28, 2015, at 22:32:27
I didn't try to read the underlying study and, for me, SSRI's didn't do much. But it makes sense that if you eliminate all the noise - sleep changes, appetite changes, feelings of guilty and so forth - and look only at symptoms unique to depression - depressive mood, suicidality - that the results would be different. What surprised me was how large the difference was.
> I've been making this argument for years.
>
> Antidepressants work, although seemingly not for most people who come to this website desperately looking for help.
>
> 1. Poop out of certain drugs for some people: Yes
> 2. Worsening of depression by certain drugs for some people: Yes
> 3. Intolerable side effects of certain drugs for some people: Yes
>
> This is the nature of the beast.
>
>
> - Scott
Posted by hello123 on May 29, 2015, at 21:22:53
In reply to Re: SSRI effectiveness - Finally ! » SLS, posted by baseball55 on May 29, 2015, at 20:11:16
i think Drug Companies need to be thoroughly scrutinized. no free ride for them. or piling on the praise. with the huge amounts of wealth they receive, they can afford to have their products and their business practices scrutinized by us. especially if tbeyre going to charge around $1,000 for a 30 day supply of Abilify.
but we need to always demand the better from them. if not for ourselves, then for others. if something isnt working as well as customers for these medications need them, we dont need to say "oh well thats alright, at least 30% of the people who take it acheive remission with it. and 25% have some symptoms improved."
the main reason why there are so many SSRI's on the market is because they were seen as money-making opportunities. and not necessarily because they were
the best possible chemicals in the Drug co's supply that might benefit patients. we always need to demand better.
Posted by Horse on May 29, 2015, at 23:09:31
In reply to SSRI effectiveness, posted by baseball55 on May 28, 2015, at 20:49:27
thanks for the link :-) Lexapro works for me...for awhile I thought it might be placebo. I mean, whichever, fine. However I've been reading and talking to my shrink about inflammation...and turns out ssri's are also anti-inflammatory. But I am far from being a scientist....
In my case, lexapro does not do everything, but it was my first real step out of the hole.
Posted by SLS on May 29, 2015, at 23:23:29
In reply to Re: SSRI effectiveness, posted by Horse on May 29, 2015, at 23:09:31
Interesting article on depression and placebo response:
http://www.slschofield.com/medicine/placebo_response_in_clinical_trials.pdf
- Scott
Posted by SLS on May 29, 2015, at 23:26:25
In reply to Re: SSRI effectiveness, posted by SLS on May 29, 2015, at 23:23:29
Also:
http://www.ncbi.nlm.nih.gov/pubmed/15589562?dopt=Abstract
http://jama.jamanetwork.com/article.aspx?articleid=185157
- Scott
Posted by hello123 on May 30, 2015, at 4:26:53
In reply to Re: SSRI effectiveness, posted by SLS on May 29, 2015, at 23:26:25
and im starting to think my thoroughly pessimistic view on mental health treatment doesnt fit in with the general thinking of users on this site. im like a strong right conservative listening to Barack Obama give a speech when it comes to someone pointing out good news on memtal health treatments. and ive only been able to get along with doctors who
are also very pessimistic about these treatments, and prefer to think outside the box that the psychiatric world insists on staying in.and its like hardly anyone hears what im saying anymore. ive experienced this before tbe last time my anhedonia was quite severe. back then i just kept my mouth shut on any topic that might offend anyone until i started feeling better.
Posted by SLS on May 30, 2015, at 9:06:07
In reply to Re: SSRI effectiveness, posted by hello123 on May 30, 2015, at 4:26:53
Hi.
> and im starting to think my thoroughly pessimistic view on mental health treatment doesnt fit in with the general thinking of users on this site.
Opinions ebb and flow on this website regarding psychiatry and the treatments it offers. You are definitely not alone in your perceptions and conclusions. Even if you were alone, you might be the only one who understands the reality of psychiatry and pharmaceutical companies. It would be a shame to lose you. Remember, though, that it is likely that the majority of people who respond well to psychiatric treatment are never in need of more information and support. They just don't come here. They have no reason to. Thus, the overwhelming majority of people posting on Psycho-Babble might represent a minority of the patient population. We probably see a very skewed representation of the mentally ill.
As for me, I am pessimistic about my own future with bipolar disorder - chronic depressive type. But that doesn't mean that I can project my singular experience to the majority. Psychiatric treatments are inadequate because they don't get everyone completely healthy and without side effects. I am very optimistic about the direction neuropsychiatric research is headed. Unfortunately, it is likely that I won't be the beneficiary of future understandings. I have been on both sides of the fence. I have seen psyhiatric treatments evolve as both a patient as well as having close relationships with researchers in the field. I tend not to be cynical because of this. In this way, I have been fortunate.
- Scott
Posted by Phillipa on May 30, 2015, at 18:44:36
In reply to Re: SSRI effectiveness, posted by Horse on May 29, 2015, at 23:09:31
Horse inflammation? In what way? And for all parts of the body? Thanks
Posted by SLS on May 31, 2015, at 0:44:46
In reply to Re: SSRI effectiveness, posted by Horse on May 29, 2015, at 23:09:31
Some people respond well to minocycline. Aside from having antibiotic properties, it is also a potent anti-inflammatory in the brain as well as a modulator of glutamate neurotransmission. Combining Lamictal with minocycline can potentiate the glutamate-lowering effects of minocycline.
http://www.dr-bob.org/babble/20120803/msgs/1023257.html
- Scott
Posted by Phillipa on May 31, 2015, at 17:36:36
In reply to Re: SSRI effectiveness » Horse, posted by SLS on May 31, 2015, at 0:44:46
Didn't you have skin problems with mino? Have they resolved
Posted by SLS on May 31, 2015, at 19:12:40
In reply to Re: SSRI effectiveness » SLS, posted by Phillipa on May 31, 2015, at 17:36:36
> Didn't you have skin problems with mino? Have they resolved
I stopped taking minocycline because of hyperpigmentation.
Minocycline can produce hyperpigmentation (a darkening) of the skin, usually of the feet and shins. It occurs in a minority of people, but I don't have the statistics. It can first emerge several years after initiating treatment. In some cases, the hyperpigmentation is irreversible. Most of mine has faded. It can take quite a few months. Minocycline sure felt nice while it lasted.
- Scott
Posted by Phillipa on May 31, 2015, at 20:25:39
In reply to Re: SSRI effectiveness » Phillipa, posted by SLS on May 31, 2015, at 19:12:40
Didn't know could appear a few years after taking it. But certainly glad yours resolved. Is this why you discontinue it? Phillipa
This is the end of the thread.
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