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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by phidippus on July 31, 2012, at 21:35:39
I recently started taking 10 mg of Abilify and my OCD has come under exquisite control.
Now, inreased dopamanergic activity is present in the nucleus acumbens in most folk with OCD. Abilify is a d2/d3 partial agonist-what's it doing to dopamine activity in my nucleus acumbens?
Eric
Posted by Phillipa on August 1, 2012, at 0:25:46
In reply to Abilify and OCD: SLS, posted by phidippus on July 31, 2012, at 21:35:39
Eric know to Scott but what kind of OCD you have? Phillipa
Posted by SLS on August 1, 2012, at 1:12:57
In reply to Abilify and OCD: SLS, posted by phidippus on July 31, 2012, at 21:35:39
> I recently started taking 10 mg of Abilify and my OCD has come under exquisite control.
>
> Now, inreased dopamanergic activity is present in the nucleus acumbens in most folk with OCD. Abilify is a d2/d3 partial agonist-what's it doing to dopamine activity in my nucleus acumbens?
>
> Eric
This is one of those questions about Abilify that I like to defer to Stephen Stahl and his conceptualization of how it acts as a dopamine system stabilizer (DSS), a dynamic unique among available neuroleptic antipsychotics (although cariprazine would be the second of these drugs if it gets approved by the US FDA this year). Stahl's thoughts are that Abilify, through its partial D2/D3 receptor agonism, acts more as a postsynaptic antagonist when synaptic concentrations of DA are high, and an agonist when concentrations are low. One idea I have is that this might be related to the ability of these DA receptors to switch from a low-affinity state to a high-affinity state via conformational change. I really don't know if anyone has proposed this as a mechanism yet.Here are some reviews that help explain the DSS actions of Abilify (aripiprazole):
jpet.aspetjournals.org/content/302/1/381.full.pdf
http://www.ncbi.nlm.nih.gov/pubmed/12065741
Several open-label studies that I came across indicated that Abilify augmentation of SRIs can improve OCD.
- Scott
Posted by phidippus on August 1, 2012, at 15:16:56
In reply to Re: Abilify and OCD: SLS » phidippus, posted by SLS on August 1, 2012, at 1:12:57
Aripiprazole is chemically different from other AA agents, acting as a weak stimulator of dopamine D2 receptors (the drug is a so-called partial agonist) with an antagonistic (inhibitory) or agonist (stimulating) activity, depending on the sensibility of the receptors and the availability of dopamine (DA). The D2 receptors are present both presynaptically (as autoinhibitory targets) and postsynaptically (as stimulating-heteroreceptors).
Eric
Posted by phidippus on August 2, 2012, at 21:23:24
In reply to Re: Abilify and OCD: SLS » phidippus, posted by Phillipa on August 1, 2012, at 0:25:46
I have 'pure o' - intrusive and recurrent thoughts. No compulsions.
I'm currently very well controlled.
Eric
Posted by Phillipa on August 3, 2012, at 20:34:38
In reply to Re: Abilify and OCD: SLS » Phillipa, posted by phidippus on August 2, 2012, at 21:23:24
Where does worry rituals, bad luck fit it as not controlled. Phillipa
Posted by phidippus on August 3, 2012, at 22:23:58
In reply to Re: Abilify and OCD: SLS » phidippus, posted by Phillipa on August 3, 2012, at 20:34:38
Compulsions usually fade when the anxiety fades.
Eric
Posted by Phillipa on August 3, 2012, at 23:22:36
In reply to Re: Abilify and OCD: SLS » Phillipa, posted by phidippus on August 3, 2012, at 22:23:58
So how to fade the anxiety? Seriously benzos don't do it. Should I add back in 2.5mg of lexapro that I stopped? Phillipa
Posted by phidippus on August 4, 2012, at 7:09:03
In reply to Re: Abilify and OCD: SLS » phidippus, posted by Phillipa on August 3, 2012, at 23:22:36
Have you ever tried Lyrica or Gabapentin?
Eric
Posted by Phillipa on August 4, 2012, at 21:02:18
In reply to Re: Abilify and OCD: SLS » Phillipa, posted by phidippus on August 4, 2012, at 7:09:03
Eric no neither of these meds. Phillipa
This is the end of the thread.
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