Psycho-Babble Medication Thread 945813

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Another question for Bleauberry

Posted by conundrum on April 30, 2010, at 23:51:27

Hey I know you read some of Gilman's stuff and I wondered if you know why he seems to prefer nortriptyline over desipramine?

 

Re: Another question for Bleauberry conundrum

Posted by Bob on May 1, 2010, at 2:12:27

In reply to Another question for Bleauberry, posted by conundrum on April 30, 2010, at 23:51:27

> Hey I know you read some of Gilman's stuff and I wondered if you know why he seems to prefer nortriptyline over desipramine?


Who is Gilman and what "stuff" are you referring to? Just curious.

 

Re: Another question for Bleauberry Bob

Posted by conundrum on May 1, 2010, at 5:44:43

In reply to Re: Another question for Bleauberry conundrum, posted by Bob on May 1, 2010, at 2:12:27

Dr. Ken Gillman is a psychiatrist I have seen Bleauberry and a couple others mention.

Here is his site. He seems to be fond of a Zoloft+Nortiptyline combo.

 

Re: Another question for Bleauberry conundrum

Posted by Phillipa on May 1, 2010, at 10:57:50

In reply to Re: Another question for Bleauberry Bob, posted by conundrum on May 1, 2010, at 5:44:43

No site unless we're crossposting. Phillipa

 

Re: Another question for Bleauberry conundrum

Posted by Bob on May 1, 2010, at 11:26:37

In reply to Re: Another question for Bleauberry Bob, posted by conundrum on May 1, 2010, at 5:44:43

> Dr. Ken Gillman is a psychiatrist I have seen Bleauberry and a couple others mention.
>
> Here is his site. He seems to be fond of a Zoloft+Nortiptyline combo.


I think you forgot to include the link for the site when you posted. I'd like to see it though.

 

Re: Another question for Bleauberry

Posted by conundrum on May 1, 2010, at 11:27:01

In reply to Re: Another question for Bleauberry Bob, posted by conundrum on May 1, 2010, at 5:44:43

Whoops here is the link.

www.psychotropical.com

Thanks Phillipa.

 

Re: Another question for Bleauberry conundrum

Posted by Bob on May 1, 2010, at 11:42:42

In reply to Re: Another question for Bleauberry, posted by conundrum on May 1, 2010, at 11:27:01

> Whoops here is the link.
>
> www.psychotropical.com
>
> Thanks Phillipa.


Oh, ok... I have actually seen that site. I can't find where he suggests the nortiptyline + sertraline combo. Sounds reasonable, but I wonder if there's any reason why he picks that SSRI over any other?

 

Re: Another question for Bleauberry Bob

Posted by conundrum on May 1, 2010, at 11:54:25

In reply to Re: Another question for Bleauberry conundrum, posted by Bob on May 1, 2010, at 11:42:42

hmm probably cuz its cheaper than celexa, way cheaper than lexapro, more effective than luvox, and better tolerated and longer half life than paxil, and maybe better tolerated and certainly less drug to drug interactions than prozac. Also the commercials have that cute blob.

 

Re: Another question for Bleauberry conundrum

Posted by Bob on May 1, 2010, at 11:59:56

In reply to Re: Another question for Bleauberry Bob, posted by conundrum on May 1, 2010, at 11:54:25

> hmm probably cuz its cheaper than celexa, way cheaper than lexapro, more effective than luvox, and better tolerated and longer half life than paxil, and maybe better tolerated and certainly less drug to drug interactions than prozac. Also the commercials have that cute blob.


I think I found where he discusses it - at the bottom of this page:

http://www.psychotropical.com/dual_action_ads.shtml


I thought sertraline was generally considered a dirtier SSRI than citalopram or escitalopram, but maybe that's just anecdotal.

 

Re: Another question for Bleauberry Bob

Posted by conundrum on May 1, 2010, at 12:12:22

In reply to Re: Another question for Bleauberry conundrum, posted by Bob on May 1, 2010, at 11:59:56

Its a dopamine reuptake inhibitor and a very weak NRI. Nothing bad about that though, the more selective the SSRI the more blunted and dumb it makes you. I'm sure the little bit of DRI could be helpful at keeping serotonin from totally squashing the effect of dopamine.

 

Re: Another question for Bleauberry conundrum

Posted by Bob on May 1, 2010, at 13:55:43

In reply to Re: Another question for Bleauberry Bob, posted by conundrum on May 1, 2010, at 12:12:22

> Its a dopamine reuptake inhibitor and a very weak NRI. Nothing bad about that though, the more selective the SSRI the more blunted and dumb it makes you. I'm sure the little bit of DRI could be helpful at keeping serotonin from totally squashing the effect of dopamine.

It's a dopamine reuptake inhibitor? I've never heard that, and I would assume that any such action would be quite weak, right?

 

Re: Another question for Bleauberry Bob

Posted by conundrum on May 1, 2010, at 14:35:37

In reply to Re: Another question for Bleauberry conundrum, posted by Bob on May 1, 2010, at 13:55:43

Well its more potent than wellbutrin, which is I guess why wellbutrin is prescribed at much higher doses, but compared to its own affinity to the serotonin transporter its very weak. So its still pretty darn selective.

 

Re: Another question for Bleauberry

Posted by bleauberry on May 1, 2010, at 18:08:17

In reply to Another question for Bleauberry, posted by conundrum on April 30, 2010, at 23:51:27

> Hey I know you read some of Gilman's stuff and I wondered if you know why he seems to prefer nortriptyline over desipramine?

Well I'm not sure. I know he has a lot of science in his thinking, but the drugs he favors are ones that seemed to be the most favorable in his actual experience. Maybe there was no difference but he just unknowinigly mentioned nortriptyline more often? Dunno.

 

Re: Another question for Bleauberry bleauberry

Posted by conundrum on May 2, 2010, at 20:19:43

In reply to Re: Another question for Bleauberry, posted by bleauberry on May 1, 2010, at 18:08:17

> > Hey I know you read some of Gilman's stuff and I wondered if you know why he seems to prefer nortriptyline over desipramine?
>
> Well I'm not sure. I know he has a lot of science in his thinking, but the drugs he favors are ones that seemed to be the most favorable in his actual experience. Maybe there was no difference but he just unknowinigly mentioned nortriptyline more often? Dunno.
>
>

I just did some research on TCAs for ADHD and it said that there is a risk of cardiac toxicity in children with desipramine. This would probably apply to adults as well. Maybe nortriptyline is just better tolerated, or maybe its more effective. When I look at what the drug does its sort of like an NRI with some of the properties of an atypical antipsychotic, except the main dopamine blocking part. How was your experience with nortriptyline?


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