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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Vincent_QC on March 26, 2009, at 7:34:53
Hi everyone!
Since my last post turning into a language post, french-english and grammaticals errors...I ask the question again...Did someone on this board try the Pristiq for social anxiety disorder? If so, is it true that it's worse the anxiety a lot at first (like the effexor do??? I was craving for more and more benzos drugs on the effexor)...
Another technical question. Pristiq it's an extended release...It take around 7.5 hours to reach the max peak level in the blood. I had a gastric by-pass who make my total digestive system with a 4 hour maximum of transit...mean that I eat and 4 hour later it's ready to go out of my body...That it mean that I will not absorb it ??? Or I will maybe absorb a small 20-30% of the dose? IF so, the recommended dose is 50mg, even if in the studies, the 100mg and 400mg groups did more well than the 50mg and the 200mg groups...So what can be my target dose is I absorb just 20-30% of one pill of 50mg??? I'm not a pharmacist and they don't seem to know the answer...I had the exact same problem with the Effexor-XR...they was unable to tell me what was the % of the dose I was absorbing ...so I was on a special super high dose of 450mg divided in 5 intakes/day...
Also, in those studies, you can see that the maximum good effect (not complete remission, just partial answer or improvements) is only a small 13%...and it's on the groups of the 400mg/day...but the FDA approved it at 50mg...the % at this dose is lesser than this... The marge between the Placebo group and the 400mg make this med not very good no or promising no???
Since we are all different, I don't want to lost another 8 weeks of my life trying something who will not help me... Did I stick and wait for the Marplan approved for the importation or I just go on trying the Pristiq??? And if I go with the Pristiq, should I expect an increase of my anxiety lever??? My anxiety level in social or general situation is already at is maximum...I mean that I have to have a HUGE control over my Valium intake to be sure I don't take more than the 20mg i'm suppose to take a day!!!!
For what I remember, last summer, when I Was put on the high dose of Effexor-XR, I was so skinny, I was not eating, I was tired as hell (no change since then), I was smooking a lot, I became addicted to high dose of Xanax, more than 8mg/day...)...I fear that the Pristiq will bring back this kind of side-effects...for the weight loose that's ok...but the increase anxiety and craving for benzos drugs it's a big NO!!!...
BUT, I can point the fact that before, I try the Celexa...and I got no answer at all and no side-effect (just weight gain) at 40mg/day... I was put on the Lexapro, the same med just the isomater inactive removed, and I had a more strong reaction, more side-effects, more weight-gain, yeah I See a small difference in my anxiety...but I was like dying and without any feeling...it was like the world can explose, I don't care...but in other hand, in social events, I was feeling quite anxious, moist hands, fast heart beat...
So another time, any good input or help, especially for the Pristiq dose with my gastric by-pass will help me a lot!
Thanks everyone!!!
Vince ;-)
Posted by Zana on March 26, 2009, at 11:54:01
In reply to Pristiq...The good, the bad (SAD and anxiety), posted by Vincent_QC on March 26, 2009, at 7:34:53
Vince, boy it sounds like you have really been struggling. I'm sorry it's been and still is so hard.
I think your surgeon or gastroenterologist is the best person to address the absorption issue. You need to talk to a specialist who has had a lot of experience with your surgury.
I can completely understand your frustration and anxiety about it. It is so difficult and seems so unfair to have tried so many things, so many ways to feel better, even just a bit and still to feel so bad.
I hope the pristiq works out for you. I may be trying it myself soon...
Posted by myco on March 26, 2009, at 12:27:31
In reply to Pristiq...The good, the bad (SAD and anxiety), posted by Vincent_QC on March 26, 2009, at 7:34:53
Vince,
If you are, in the long run, waiting on Marplan anyway...why not go back to Nardil again. You already mentioned it works the best so far of anything so why not retry it at a higher dose or with augments while you wait out Marplan. Marplan is similar enough to Nardil anyway and might be a better option. You could be waiting for a long time and they may turn around and say no Vince Health Canada won't allow its importation. I am sure I would be rejected in days if I asked for Marplan lol
------------------
> Hi everyone!
> Since my last post turning into a language post, french-english and grammaticals errors...I ask the question again...
>
> Did someone on this board try the Pristiq for social anxiety disorder? If so, is it true that it's worse the anxiety a lot at first (like the effexor do??? I was craving for more and more benzos drugs on the effexor)...
>
> Another technical question. Pristiq it's an extended release...It take around 7.5 hours to reach the max peak level in the blood. I had a gastric by-pass who make my total digestive system with a 4 hour maximum of transit...mean that I eat and 4 hour later it's ready to go out of my body...That it mean that I will not absorb it ??? Or I will maybe absorb a small 20-30% of the dose? IF so, the recommended dose is 50mg, even if in the studies, the 100mg and 400mg groups did more well than the 50mg and the 200mg groups...So what can be my target dose is I absorb just 20-30% of one pill of 50mg??? I'm not a pharmacist and they don't seem to know the answer...I had the exact same problem with the Effexor-XR...they was unable to tell me what was the % of the dose I was absorbing ...so I was on a special super high dose of 450mg divided in 5 intakes/day...
>
> Also, in those studies, you can see that the maximum good effect (not complete remission, just partial answer or improvements) is only a small 13%...and it's on the groups of the 400mg/day...but the FDA approved it at 50mg...the % at this dose is lesser than this... The marge between the Placebo group and the 400mg make this med not very good no or promising no???
>
> Since we are all different, I don't want to lost another 8 weeks of my life trying something who will not help me... Did I stick and wait for the Marplan approved for the importation or I just go on trying the Pristiq??? And if I go with the Pristiq, should I expect an increase of my anxiety lever??? My anxiety level in social or general situation is already at is maximum...I mean that I have to have a HUGE control over my Valium intake to be sure I don't take more than the 20mg i'm suppose to take a day!!!!
>
> For what I remember, last summer, when I Was put on the high dose of Effexor-XR, I was so skinny, I was not eating, I was tired as hell (no change since then), I was smooking a lot, I became addicted to high dose of Xanax, more than 8mg/day...)...I fear that the Pristiq will bring back this kind of side-effects...for the weight loose that's ok...but the increase anxiety and craving for benzos drugs it's a big NO!!!...
>
> BUT, I can point the fact that before, I try the Celexa...and I got no answer at all and no side-effect (just weight gain) at 40mg/day... I was put on the Lexapro, the same med just the isomater inactive removed, and I had a more strong reaction, more side-effects, more weight-gain, yeah I See a small difference in my anxiety...but I was like dying and without any feeling...it was like the world can explose, I don't care...but in other hand, in social events, I was feeling quite anxious, moist hands, fast heart beat...
>
> So another time, any good input or help, especially for the Pristiq dose with my gastric by-pass will help me a lot!
>
> Thanks everyone!!!
>
> Vince ;-)
Posted by Phillipa on March 26, 2009, at 12:27:32
In reply to Re: Pristiq...The good, the bad (SAD and anxiety), posted by Zana on March 26, 2009, at 11:54:01
Vincent I agree with above poster you do have a lot to consider. Especially with high anxiety. Love Phillipa
Posted by Vincent_QC on March 26, 2009, at 14:11:10
In reply to Re: Pristiq...The good, the bad (SAD and anxiety) » Vincent_QC, posted by myco on March 26, 2009, at 12:27:31
> Vince,
>
> If you are, in the long run, waiting on Marplan anyway...why not go back to Nardil again. You already mentioned it works the best so far of anything so why not retry it at a higher dose or with augments while you wait out Marplan. Marplan is similar enough to Nardil anyway and might be a better option. You could be waiting for a long time and they may turn around and say no Vince Health Canada won't allow its importation. I am sure I would be rejected in days if I asked for Marplan lol
>
> ------------------Well, the facts are that I have a complicated medical folder with tons of documented tries and at this stage, health Canada will probably say yes, that's a matter of time... The PDoc get others patients approved for others meds from the States, patiens who don't try everything avaible in the Canada...so why I will be refuse on the SPA program? I wonder why...
I think try the Prisqiq by myself will be the more smarter move to do... divided the dose in 4 intakes crush the pills...we will see...I have nothing to loose...
For the Nardil VS Marplan we can debate a long time on it...Old studies and litterature show a lesser side-effects profile, with less problem with the blood pressure and orthostatic hypotension...Remember that I got no improve on 75mg of Nardil...and when I hit the 90mg, I had the worst time of my life, at the time, and I Was not able to cope with the orthostatic hypotension...Now with my high blood pressure problem that I got since the Parnate experience and that never fade away, i'm scare to be back on a MAOI...that's normal no? It's look like I change my minds often since a couple of days...did I should take 10mg of Parnate/day without telling my PDoc, should I just wait until my next appointment, should I try the Pristiq, should I just wait...should I try the Cymbalta...the only other one SRNI I never try...shoul I try the luvox??? So many question, too less answer...
For Xana... The Doctor who do the gastric by-pass don't know the impact of the extended release effect on the people who get the surgery...I ask so many times...I just succeed to have a short answer like the ordinary formulation work ...take one of them...wow...very helping!!! They don't know , nobody know...they do this surgery and leave the people alone after with all the problems, psychologics and physicals... they have too many patients to take care of...not a lot of money to run the place...it's like this...I got this surgery, I live with the consequences...I accept them...
This is the end of the thread.
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