Psycho-Babble Medication Thread 780714

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NMDA Antagonists for Bipolar Depression

Posted by Jimmyboy on September 4, 2007, at 0:12:01

Has anyone tried various NMDa antagonists like amantadine, riluzole, or memantine to treat bipolar depression? If so, was it effective at all?

I am particularly interested to know if anyone has tried the amantadine or memantine because the riluzole is way way to expensive to ever consider.

Also, I think I read somewhere that magnesium was an NMDA antagonist, would this have the same effect? Thanks

JB

 

Re: NMDA Antagonists for Bipolar Depression

Posted by linkadge on September 4, 2007, at 8:04:52

In reply to NMDA Antagonists for Bipolar Depression, posted by Jimmyboy on September 4, 2007, at 0:12:01

Magnesium and Zinc are NMDA antagonists and both have effect on mood in some cases of depression, thought they have secondary effects which make them differ.

I think theanine has some NMDA affinity.

SLS, if you remember him, tried Riluzole, but I don't think he noticed too much effect. It was for bipolar depression.

Linkadge

 

Re: NMDA Antagonists for Bipolar Depression linkadge

Posted by Jimmyboy on September 4, 2007, at 10:50:41

In reply to Re: NMDA Antagonists for Bipolar Depression, posted by linkadge on September 4, 2007, at 8:04:52

Thanks for the input,

I was looking at some abstracts on riluzole and it indicated that it may work for bipolar depression by regulating glutamate, do all NMDA antagonists do this?

JB

 

Re: NMDA Antagonists for Bipolar Depression linkadge

Posted by Phillipa on September 4, 2007, at 12:15:57

In reply to Re: NMDA Antagonists for Bipolar Depression, posted by linkadge on September 4, 2007, at 8:04:52

Link do you remember the final meds Scott is on? That link might help another as isn't he bipolar too? Phillipa

 

Re: NMDA Antagonists for Bipolar Depression

Posted by linkadge on September 4, 2007, at 14:06:41

In reply to Re: NMDA Antagonists for Bipolar Depression linkadge, posted by Phillipa on September 4, 2007, at 12:15:57

I am certainly not an expert on the workings of glutamate modulating agents.

There are compounds that modulate glutmate which are not NMDA antagonists.

Vitamin C, for instance, has antiglutamatergic properties, but is not an NMDA antagonist.

Linkadge


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