Psycho-Babble Medication Thread 775053

Shown: posts 1 to 11 of 11. This is the beginning of the thread.

 

SSRI's effect on norepinephrine ???

Posted by Glydin on August 9, 2007, at 13:44:37

I thought SSRI's, as a drug class, were very weak reuptake inhibitor of norepinephrine to the point of very little impact on norepi unlike SNRI's.....

Can someone clarify this for me?

 

Re: SSRI's effect on norepinephrine ??? Glydin

Posted by Jay_Bravest_Face on August 9, 2007, at 16:43:00

In reply to SSRI's effect on norepinephrine ???, posted by Glydin on August 9, 2007, at 13:44:37

> I thought SSRI's, as a drug class, were very weak reuptake inhibitor of norepinephrine to the point of very little impact on norepi unlike SNRI's.....
>
> Can someone clarify this for me?

If I recall correctly, Paxil is supposedly the most potent NRI that is classified as an SRI out of the drugs available in N. America. There has been some really huge arguments over the past few years about it even labeling Paxil, Prozac, Zoloft et al, as just "SSRI's". Some of their strongest characteristics may be the influence on Serotonin, but they certainly have been shown to affect numerous/and/or most .at least some of the other neurotransmitters. It all really came down to marketing. The drug companies wanted to present a "clean" a.d. that addressed their (ill thought-up) idea that Serotonin is/was the only major player in depression.(This is particularly true going back to the original launch of Prozac here in N. America. Prozac also effects both some dopamine and norepinephrine. EVERYTHING was linked to Serotonin) It is just they all have different "ratios" of how much the drug affects a particular neurotransmitter. Yes, some affect Serotonin more then others, but "SSRI" may be misleading.

Jay :)

 

Re: SSRI's effect on norepinephrine ??? Jay_Bravest_Face

Posted by King of Nothing on August 9, 2007, at 17:02:24

In reply to Re: SSRI's effect on norepinephrine ??? Glydin, posted by Jay_Bravest_Face on August 9, 2007, at 16:43:00

> > I thought SSRI's, as a drug class, were very weak reuptake inhibitor of norepinephrine to the point of very little impact on norepi unlike SNRI's.....
> >
> > Can someone clarify this for me?
>
> If I recall correctly, Paxil is supposedly the most potent NRI that is classified as an SRI out of the drugs available in N. America. There has been some really huge arguments over the past few years about it even labeling Paxil, Prozac, Zoloft et al, as just "SSRI's". Some of their strongest characteristics may be the influence on Serotonin, but they certainly have been shown to affect numerous/and/or most .at least some of the other neurotransmitters. It all really came down to marketing. The drug companies wanted to present a "clean" a.d. that addressed their (ill thought-up) idea that Serotonin is/was the only major player in depression.(This is particularly true going back to the original launch of Prozac here in N. America. Prozac also effects both some dopamine and norepinephrine. EVERYTHING was linked to Serotonin) It is just they all have different "ratios" of how much the drug affects a particular neurotransmitter. Yes, some affect Serotonin more then others, but "SSRI" may be misleading.
>
> Jay :)

Great information Jay, Thank you.

 

Re: SSRI's effect on norepinephrine ???

Posted by Phillipa on August 9, 2007, at 17:41:01

In reply to Re: SSRI's effect on norepinephrine ??? Jay_Bravest_Face, posted by King of Nothing on August 9, 2007, at 17:02:24

False advertising. Love Phillipa but would explain why most hype me up but not luvox but be the only true SSRI.

 

Re: SSRI's effect on norepinephrine ??? Phillipa

Posted by gardenergirl on August 9, 2007, at 19:12:56

In reply to Re: SSRI's effect on norepinephrine ???, posted by Phillipa on August 9, 2007, at 17:41:01

> False advertising. Love Phillipa but would explain why most hype me up but not luvox but be the only true SSRI.

I don't think so. Life is not a series of either/or, all/nothing, black/white, good/bad, yes/no, or other dichotomous decisions--not even for any one person. It's much more complex, as are neurochemistry and pharmokinetics.

gg

 

Re: SSRI's effect on norepinephrine ??? gardenergirl

Posted by Phillipa on August 9, 2007, at 21:56:08

In reply to Re: SSRI's effect on norepinephrine ??? Phillipa, posted by gardenergirl on August 9, 2007, at 19:12:56

Low dose luvox works for me no side effects the only one so it's my drug of choice. Love Phillipa

 

Re: SSRI's effect on norepinephrine ??? Phillipa

Posted by gardenergirl on August 9, 2007, at 22:19:58

In reply to Re: SSRI's effect on norepinephrine ??? gardenergirl, posted by Phillipa on August 9, 2007, at 21:56:08

I'm glad it works well for you. But it's not "the only true SSRI." That's what I was commenting on.

gg

 

Re: SSRI's effect on norepinephrine ??? gardenergirl

Posted by Phillipa on August 9, 2007, at 22:34:24

In reply to Re: SSRI's effect on norepinephrine ??? Phillipa, posted by gardenergirl on August 9, 2007, at 22:19:58

GG sorry well according to this thread what is then as I always was under the impression prozac, celexa, paxil, zoloft, luvox and I probably left some out all were? Love Phillipa oops lexapro

 

Those are all SSRIs. (nm) Phillipa

Posted by gardenergirl on August 9, 2007, at 22:39:24

In reply to Re: SSRI's effect on norepinephrine ??? gardenergirl, posted by Phillipa on August 9, 2007, at 22:34:24

 

Re: SSRI's effect on norepinephrine ??? Glydin

Posted by nellie7 on August 10, 2007, at 8:49:02

In reply to SSRI's effect on norepinephrine ???, posted by Glydin on August 9, 2007, at 13:44:37

Hi Glydin,

I was once told that celexa is the "cleanest" SSRI in terms of the effect on serotonin. That would include lexapro as well.

Nellie.

 

Re: Those are all SSRIs. gardenergirl

Posted by Phillipa on August 10, 2007, at 20:02:08

In reply to Those are all SSRIs. (nm) Phillipa, posted by gardenergirl on August 9, 2007, at 22:39:24

GG I know that is my point so why are some saying norepenephrine and dopamine? As far as I know all the above mentioned are SSRI's only SNRI's being effexor and cymbalta. Love Phillipa


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