Psycho-Babble Medication Thread 689052

Shown: posts 1 to 10 of 10. This is the beginning of the thread.

 

how strong is buspar's D2 antagonism?

Posted by iforgotmypassword on September 25, 2006, at 10:35:54

what doses would it be a active at? i experience EPS since SSRIs, even though not currently on them. concerns over D2 activity, as i am paradoxically trying to see if buspar will *help*.

anhedonia, apathy, extreme lethargy and amotivation are SERIOUS problems, which brings another concern over antidopaminergic effects. any chance that at whatever dose, it may only hit the AUTOreceptors?

 

Re: how strong is buspar's D2 antagonism?

Posted by linkadge on September 25, 2006, at 10:55:43

In reply to how strong is buspar's D2 antagonism?, posted by iforgotmypassword on September 25, 2006, at 10:35:54

I was wondering the same thing myself of late. From looking on PDSP, it seems that the buspar's affinity for d2 is still somewhat less than it is for 5-ht1a.

Its possable that for some, the d2 antagonism could contribute to the anti-anxiety effect.

Its one med I have wanted to try.

Linkadge

 

Re: how strong is buspar's D2 antagonism?

Posted by med_empowered on September 25, 2006, at 12:17:17

In reply to Re: how strong is buspar's D2 antagonism?, posted by linkadge on September 25, 2006, at 10:55:43

I dont know how strong it is but..you might feel it. I did. At first I just felt calmer; then it felt kinda of akathisia-esque, only at a lower intensity (and somehow, it felt creepy and weird). At 60mgs/day, I pretty much had straight up akathisia. There have been a couple cases of TD attributed to buspar.

 

Re: how strong is buspar's D2 antagonism? med_empowered

Posted by iforgotmypassword on September 25, 2006, at 13:27:16

In reply to Re: how strong is buspar's D2 antagonism?, posted by med_empowered on September 25, 2006, at 12:17:17

dogfarnit. akithasia/bruxism/rigidity/etc is what i am trying to cure by taking it. i am likely going to try it anyway. it seems to be generic in canada. otherwise maybe i'll try pindolol (?), or keep trying to get ect.

any news on gepirone or other family members coming back from the dead?

 

Re: how strong is buspar's D2 antagonism? linkadge

Posted by iforgotmypassword on September 25, 2006, at 13:29:27

In reply to Re: how strong is buspar's D2 antagonism?, posted by linkadge on September 25, 2006, at 10:55:43

is there any way to find out clearly whether it may be selective towards pre-synaptic D2 autoreceptors? maybe at certain doses?

 

Re: how strong is buspar's D2 antagonism? iforgotmypassword

Posted by linkadge on September 25, 2006, at 15:34:49

In reply to Re: how strong is buspar's D2 antagonism? linkadge, posted by iforgotmypassword on September 25, 2006, at 13:29:27

I was under the impression that it was a postsynaptic d2 receptor antagonist. I didn't know of any affinity for presynaptic receptors.

It has a short half life, so at moderate doses I wound't be too concerned about permamant movement problems.

You could always try it with a dopamine agonist to counteract that side effect.

I always thought that buspar + mirapex would be very interesting. Combined dopamine + serotonin agonism.

Certain herbs like skullcap combine 5-ht1a agonism and d1 agonism.

Linkadge


 

mirapex was wierd for me linkadge

Posted by iforgotmypassword on September 25, 2006, at 16:00:18

In reply to Re: how strong is buspar's D2 antagonism? iforgotmypassword, posted by linkadge on September 25, 2006, at 15:34:49

caused somnolence and cognitive fuzziness. was not good for mood at all.

my doctor thought i was getting better. maybe it cut off my negative outward signs or something... (in that case, thats an eerily SSRI-like effect for me)

one thing to note about Mirapex (pramipexole) is while the D3 activity is interesting, it seems to have a doumented higher affinity for dopamine AUTORECEPTORS, speaking of the devil.

at high doses though maybe this would not matter. sure enough, in studies judging non-parkinsonian, non-geriatric, neuropsychiatric theraputic effects, HIGH DOSES SEEMED TO BE THE WAY TO GO.

my doctor was extremely conservative with the dosing and very slow with increases. i do not believe i even got past 1.5mg. maybe i didn't even get that far.

ropinirole or whatever its called may be interesting as well though... it seems to have D3 action and may even have less presynaptic selectivity.

i guess all this is YMMV though on so many levels.

your symptoms, your physiology, and finally your doctor's mindset. :(

 

Re: mirapex was wierd for me

Posted by linkadge on September 25, 2006, at 18:54:00

In reply to mirapex was wierd for me linkadge, posted by iforgotmypassword on September 25, 2006, at 16:00:18

Presynaptic dopamine autoreceptor agonism may not be a bad thing. Perhaps long term use would downregulate the autoreceptors ?

Linkadge

 

Re: mirapex was wierd for me

Posted by Phillipa on September 25, 2006, at 19:41:48

In reply to Re: mirapex was wierd for me, posted by linkadge on September 25, 2006, at 18:54:00

When I took buspar it was given in 5mg doses so didn't do a thing for me. I heard they raised the dosesages. Love Phillipa

 

Re: mirapex was wierd for me Phillipa

Posted by iforgotmypassword on September 25, 2006, at 22:17:32

In reply to Re: mirapex was wierd for me, posted by Phillipa on September 25, 2006, at 19:41:48

yeah. i don't expect much either, but i still have severe daytime bruxism (molars are flat and shorter on one side), wierd facial symptoms, akithasia like agitation pretty regularly. my jerks are only seldom now though.

i'm kind of hoping that it takes that wierd energy that i do have, and settles it so i can actually do something.


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