Psycho-Babble Medication Thread 493360

Shown: posts 1 to 11 of 11. This is the beginning of the thread.

 

Nardil and Parnate in lower doses

Posted by Declan on May 3, 2005, at 21:16:08

I'd like to try either of these. Anyone know if smaller doses are at all effective. Can smaller doses be useful? Or is it all or nothing? Can you take just enough so the side effects (insomnia,weight gain, etc.) don't work against you too much?
Declan

 

Re: Nardil and Parnate in lower doses

Posted by Joe1 on May 3, 2005, at 22:42:19

In reply to Nardil and Parnate in lower doses, posted by Declan on May 3, 2005, at 21:16:08

The new Nardil has lots of side effects with out much medical help.
Parnate works quick and has little side effects.
Just don't take it after 1-2 pm as it takes
a long time to kick in.

 

Re: Nardil and Parnate in lower doses

Posted by cubbybear on May 5, 2005, at 11:00:56

In reply to Re: Nardil and Parnate in lower doses, posted by Joe1 on May 3, 2005, at 22:42:19

Everyone reacts differently to different meds. I've been taking Parnate for 20 years and most of the time, I derive best benefits at 30 mg/day. The undesireable side effects always disappeared within a few weeks after starting or re-starting it.
Side effects are a whole separate issue, but as far as dosage goes, there are many people who do well on low doses.

 

Re: Nardil and Parnate in lower doses

Posted by Joe1 on May 5, 2005, at 20:41:03

In reply to Re: Nardil and Parnate in lower doses, posted by cubbybear on May 5, 2005, at 11:00:56

cubbybear , how are you doing. This is my fourth
month on parnate .I was wondering if you could tell me since you've taken it for so long.According to my PDR it used to be a hard
shell pill.If this is true did you notice any changes in how it worked for you.They did that to me with the Nardil the new Nardil is junk and
stopped working completely for me.I take 4-5
parnate pills/day. It doesn't seem to have any
activating effect. Have you had this problem?
Marplan is the last maoi and i think you said
it takes about 5wks to kick-in.And it's pretty
much like parnate.It sounds like it works good for you.Any info will help and thanks for your
help in the past.
Joe

 

Re: Nardil and Parnate in lower doses » Joe1

Posted by cubbybear on May 6, 2005, at 1:25:14

In reply to Re: Nardil and Parnate in lower doses, posted by Joe1 on May 5, 2005, at 20:41:03

> cubbybear , how are you doing. This is my fourth
> month on parnate .I was wondering if you could tell me since you've taken it for so long.According to my PDR it used to be a hard
> shell pill.
I don't believe the shell or coating has changed at all since I started taking Parnate in 1984. It has been around since long before that, so *maybe* the coating was different in the early years.

If this is true did you notice any changes in how it worked for you.
It has always been a lifesaver for me. I've had a couple of instances of breakthrough anxsiety where I had to increase my dose from 30-40 mg/day, but then after the crisis passed, I dropped back down to 30 mg. Otherwise, thank Heaven it has been a consistent help all these years.

It doesn't seem to have any
> activating effect. Have you had this problem?
People talk about Parnate having an activating effect at the beginning since there's a chemical similarity to amphetamine, but I can't say that I ever really thought of it being *so* activating at the beginning. It has always taken about 2-4 weeks to kick in, i.e. exert its full anti-depressant/anti-anxiety effect but I've never felt really wired on it.
I've never taken Nardil. If for whatever reason, Parnate became unavilable (hopefuly that won't happen, EVER), I would switch to Marplan since my research shows that I'd probably do better on it than on Nardil.

 

Re: Nardil and Parnate in lower doses Joe1

Posted by Declan on May 6, 2005, at 8:58:36

In reply to Re: Nardil and Parnate in lower doses Joe1, posted by cubbybear on May 6, 2005, at 1:25:14

Why would that be? I'd always thought it was a question of strength. What do Marplan and Parnate have in common in their therapeutic profile?
Declan

 

Re: Nardil and Parnate in lower doses » Declan

Posted by cubbybear on May 6, 2005, at 10:08:57

In reply to Re: Nardil and Parnate in lower doses Joe1, posted by Declan on May 6, 2005, at 8:58:36

> Why would that be? I'd always thought it was a question of strength. What do Marplan and Parnate have in common in their therapeutic profile?
> Declan

I don't think that "strength" is a term used in the clinical sense,although I guess that if a person found one AD very helpful, to him/her it would be stronger than one which was only partially helpful.

As for Parnate and Marplan, when I researched and compared the two (as well as Nardil) , I looked at efficacy vs. my own depression symptoms such anxiety, loss of appetite, premature sleep awakening, etc. (To this day I don't know if my unipolar depression would be labelled endogenous, abnormal, or whatever labels DSM has got. I seem to have some symptoms from one kind of depression and some symptoms from another.)

However, It appears from my research that Marplan definitely has more suitability compared to Nardil for my kind of depression.

I also researched side effects of all three MAOIs, and it seems that the side effect profile of Marplan is more benign and tolerable than that of Nardil. Conversely, some of the side effects/problems I've seen reported with Nardil got me concerned, such as higher risk of liver toxicity and somewhat greater likelihood of hypertensive crisis on Nardil.

Maybe I'm just being paranoid but I don't trust the drug companies, especially Glaxo Smith Kline, mfr. of Parnate, and I thought, what MAOI would I fall back on *if* Parnate was ever discontinued or impossibly expensive? the answer for me was Marplan.

So briefly, I based my comment just on researching published reports and comparisons.
I hope this answers your question.

cubbybear

 

Re: Nardil and Parnate in lower doses

Posted by cybercafe on May 9, 2005, at 6:12:38

In reply to Re: Nardil and Parnate in lower doses, posted by cubbybear on May 5, 2005, at 11:00:56

> Everyone reacts differently to different meds. I've been taking Parnate for 20 years and most of the time, I derive best benefits at 30 mg/day. The undesireable side effects always disappeared within a few weeks after starting or re-starting it.
> Side effects are a whole separate issue, but as far as dosage goes, there are many people who do well on low doses.

parnate is awesome. 30 mg/day for 2 years now and i went from years of depression to never being depressed. i actually feel like i'm becoming soft -- i imagine when i was depressed i must have had a lot of willpower to keep going.

it's so weird to live this double life. i can't even remember what it was like to be manic or depressed. when i see myself on video i'm like "god... that guy looks really out of it.". Haha

 

Re: Nardil and Parnate in lower doses » cybercafe

Posted by cubbybear on May 9, 2005, at 9:32:52

In reply to Re: Nardil and Parnate in lower doses, posted by cybercafe on May 9, 2005, at 6:12:38

> parnate is awesome. 30 mg/day for 2 years now and i went from years of depression to never being depressed. i actually feel like i'm becoming soft -- i imagine when i was depressed i must have had a lot of willpower to keep going.
>
> it's so weird to live this double life. i can't even remember what it was like to be manic or depressed. when i see myself on video i'm like "god... that guy looks really out of it.". Haha

Congratulations
-I've seen your name on this board on and off for several years now. Just curious--have you ever tried Nardil or Marplan and if so, what happened?
cubbybear

 

Re: Nardil and Parnate in lower doses cubbybear

Posted by KaraS on May 9, 2005, at 16:12:28

In reply to Re: Nardil and Parnate in lower doses Declan, posted by cubbybear on May 6, 2005, at 10:08:57

> I also researched side effects of all three MAOIs, and it seems that the side effect profile of Marplan is more benign and tolerable than that of Nardil. Conversely, some of the side effects/problems I've seen reported with Nardil got me concerned, such as higher risk of liver toxicity and somewhat greater likelihood of hypertensive crisis on Nardil.


Hi cubbybear,

Everything I've read has said that Parnate has the greatest likelihood of hypertensive crisis (or are you just comparing Nardil with Marplan here?)

Also, since Marplan is also a hydrazine, I assumed it had just as much liver toxicity potential as Nardil. Am I wrong here?

I'm not trying to nitpick here. I just really want to get my facts straight since I'm getting closer to choosing one of the MAOIs myself.

Thanks,
Kara


 

Re: Nardil and Parnate in lower doses cybercafe

Posted by cybercafe on May 12, 2005, at 2:12:44

In reply to Re: Nardil and Parnate in lower doses cybercafe, posted by cubbybear on May 9, 2005, at 9:32:52

> > parnate is awesome. 30 mg/day for 2 years now and i went from years of depression to never being depressed. i actually feel like i'm becoming soft -- i imagine when i was depressed i must have had a lot of willpower to keep going.
> >
> > it's so weird to live this double life. i can't even remember what it was like to be manic or depressed. when i see myself on video i'm like "god... that guy looks really out of it.". Haha
>
> Congratulations
> -I've seen your name on this board on and off for several years now. Just curious--have you ever tried Nardil or Marplan and if so, what happened?
> cubbybear
>
>

Nope never tried the other two! I thought going through 3 SSRIs was enough! ... funny... now that i can spot an SSRI at 30 feet, i notice some popular and/or wealthy people take this stuff, but no one really has a clue


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